Association of genetic variants in CHEK2 with oesophageal squamous cell carcinoma in the South African Black population

Author:

Chen Wenlong C123ORCID,Bye Hannah4,Matejcic Marco5,Amar Ariella4,Govender Dhiren6,Khew Yee Wen4,Beynon Victoria4,Kerr Robyn3,Singh Elvira17,Prescott Natalie J4,Lewis Cathryn M48,Babb de Villiers Chantal3,Parker M Iqbal5,Mathew Christopher G234

Affiliation:

1. National Cancer Registry, National Health Laboratory Service, Johannesburg, South Africa

2. Sydney Brenner Institute for Molecular Bioscience, University of the Witwatersrand, Johannesburg, South Africa

3. Division of Human Genetics, School of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa

4. Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom

5. Division of Medical Biochemistry and Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa

6. Division of Anatomical Pathology, University of Cape Town, Cape Town, South Africa

7. School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

8. Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, United Kingdom

Funder

Cancer Association of South Africa

University of the Witwatersrand Research Council

National Research Foundation of South Africa

German Academic Exchange Service-National Research Foundation

National Research Foundation and Department of Science and Technology Thuthuka fund

Boehringer Ingelheim Fonds

The Grants, Innovation and Product Development Unit

South African Medical Research Council

King’s Health Partner’s Research and Development Challenge Fund

South African Medical Research Council Newton

National Institute for Health Research Biomedical Research Centre at South London

Maudsley National Health Service Foundation Trust

St Thomas’ National Health Service Foundation Trust

National Institute for Health Research or the Department of Health and Social Care

South African National Department of Health

King’s College London

Wellcome Trust

National Institute for Health Research Biomedical Research Centre

GlaxoSmithKline via the Newton Fund

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference38 articles.

1. Global incidence of oesophageal cancer by histological subtype in 2012;Arnold;Gut,2015

2. National Cancer Registry. Cancer in South Africa 2014 Full Report. http://www.nioh.ac.za/assets/files/2014%20NCR%20tables.pdf (1 May 2018, date last accessed).

3. Epidemiology of esophageal squamous cell carcinoma;Abnet;Gastroenterology,2018

4. International cancer seminars: a focus on esophageal squamous cell carcinoma;Murphy;Ann. Oncol.,2017

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