Lessons learned from merging wet lab experiments with molecular simulation to improve mAb humanization-Reference-Cited by-同舟云学术

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Lessons learned from merging wet lab experiments with molecular simulation to improve mAb humanization

Published:2018-05-11 Issue:7-8 Volume:31 Page:257-265
ISSN:1741-0126
Container-title:Protein Engineering, Design and Selection
language:en
Short-container-title:

Author:

Schwaigerlehner L¹,Pechlaner M²,Mayrhofer P¹,Oostenbrink C²,Kunert R¹

Affiliation:

1. Department of Biotechnology, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, Austria

2. Department of Material Sciences and Process Engineering, University of Natural Resources and Life Sciences, Muthgasse 18, Vienna, Austria

Funder

Austrian Science Fund

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,Bioengineering,Biotechnology

Link

http://academic.oup.com/peds/article-pdf/31/7-8/257/26757245/gzy009.pdf

Reference62 articles.

1. Identification of differences in the specificity-determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoires

2. Differential Efficiency of Expression of Humanized Antibodies in Transient Transfected Mammalian Cells

3. Molecular dynamics with coupling to an external bath

4. Interaction Models for Water in Relation to Protein Hydration

5. Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions

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1. Pembrolizumab Induces an Unexpected Conformational Change in the CC′-loop of PD-1;Cancers;2020-12-22

2. A Humanized Antibody against LRG1 that Inhibits Angiogenesis and Reduces Retinal Vascular Leakage;2020-07-25

3. Engineering Stability, Viscosity, and Immunogenicity of Antibodies by Computational Design;Journal of Pharmaceutical Sciences;2020-05

4. Germinality does not necessarily define mAb expression and thermal stability;Applied Microbiology and Biotechnology;2019-07-26

5. Breast cancer mutation in GATA3 zinc finger 1 induces conformational changes leading to the closer binding of ZnFn2 with a wrapping architecture;Journal of Biomolecular Structure and Dynamics;2019-05-20

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