Increased Fab thermoresistance via VH-targeted directed evolution-Reference-Cited by-同舟云学术

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Increased Fab thermoresistance via VH-targeted directed evolution

Published:2015-08-16 Issue:10 Volume:28 Page:365-377
ISSN:1741-0126
Container-title:Protein Engineering Design and Selection
language:en
Short-container-title:Protein Engineering, Design and Selection

Author:

Entzminger Kevin C.,Johnson Jennifer L.,Hyun Jeongmin,Lieberman Raquel L.,Maynard Jennifer A.

Funder

National Institutes of Health

Welch Foundation

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,Bioengineering,Biotechnology

Link

http://academic.oup.com/peds/article-pdf/28/10/365/17495349/gzv037.pdf

Reference54 articles.

1. Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

2. How enzymes adapt: lessons from directed evolution

3. Coupling mammalian cell surface display with somatic hypermutation for the discovery and maturation of human antibodies

4. Structure-Guided Design of Antibodies

5. Potent antibody therapeutics by design

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