Engineering of 1-antitrypsin variants with improved specificity for the proprotein convertase furin using site-directed random mutagenesis
Author:
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Biochemistry,Bioengineering,Biotechnology
Link
http://academic.oup.com/peds/article-pdf/26/2/123/4367988/gzs091.pdf
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1. Furin-, ADAM 10-, and γ-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of β-Catenin's Transcriptional Activity
2. Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.
3. Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cells
4. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
5. Circulating proalbumin associated with a variant proteinase inhibitor
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