Engineering of the upper hinge region of human IgG1 Fc enhances the binding affinity to FcγIIIa (CD16a) receptor isoform
Author:
Affiliation:
1. Health Biotechnology Program, Department of Life Sciences, College of Graduate Studies, Arabian Gulf University, Manama, Kingdom of Bahrain
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Biochemistry,Bioengineering,Biotechnology
Link
http://academic.oup.com/peds/article-pdf/31/6/205/26188095/gzy019.pdf
Reference39 articles.
1. Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa
2. Effect of FCGR polymorphism on the occurrence of late-onset neutropenia and flare-free survival in rheumatic patients treated with rituximab
3. A monoclonal antibody against hinge-cleaved IgG restores effector function to proteolytically-inactivated IgGs in vitro and in vivo
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