Use of omics analysis for low-dose radiotoxicology and health risk assessment: the case of uranium

Author:

Grison Stéphane1ORCID,Souidi Maâmar1

Affiliation:

1. Institut de Radioprotection et de Sûreté Nucléaire, PSE-SANTE , F-92262 Fontenay-aux-Roses Cedex, France

Abstract

Abstract Exposure to environmental pollution and the increase in the incidence of multifactorial diseases in the population have become health problems for industrialized countries. In this context, the question of the health impact of exposure to these pollutants is not clearly identified in the low-dose range. This article looks at this problem using the example of preclinical studies of the effects of chronic low-dose exposure to uranium in rats. These studies demonstrate the value of molecular screening analyses (omics) and multimodal integrative approaches, of which the extreme sensitivity and breadth of observation spectrum make it possible to observe all the biological processes affected and the mechanisms of action triggered at the molecular level by exposure to low doses. They also show the value of these analytical approaches for finding diagnostic biomarkers or indicators of prognosis, which can be necessary to evaluate a risk. Finally, the results of these studies raise the question of the health risk caused by epigenomic deregulations occurring during critical developmental phases and their potential contribution to the development of chronic diseases that are metabolic in origin or to the development of certain cancer liable in the long term to affect the exposed adult and possibly its progeny.

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Genetics,Molecular Biology

Reference76 articles.

1. Toxicity of depleted uranium;Priest;Lancet,2001

2. Éditions Tec & Doc. Lavoisier Éditions médicales internationales;Ménager,2009

3. Depleted and natural uranium: chemistry and toxicological effects;Craft;J Toxicol Environ Health B Crit Rev,2004

4. L‘essentiel sur… L’uranium;CEA,2017

5. Depleted Uranium: Sources, Exposure and Health Effects;World Health Organization,2001

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