DNA methylation signatures as biomarkers of socioeconomic position-Reference-Cited by-同舟云学术

DNA methylation signatures as biomarkers of socioeconomic position

Published:2022-12-14 Issue:1 Volume:9 Page:
ISSN:2058-5888
Container-title:Environmental Epigenetics
language:en
Short-container-title:

Author:

Rajaprakash Meghna¹²^ORCID,Dean Lorraine T³^ORCID,Palmore Meredith³,Johnson Sara B²⁴⁵,Kaufman Joan⁶,Fallin Daniele M⁴⁷⁸,Ladd-Acosta Christine⁴⁷

Affiliation:

1. Department of Neurology and Developmental Medicine, Kennedy Krieger Institute , Baltimore, MD 21205, USA

2. Department of Pediatrics, Johns Hopkins University School of Medicine , Baltimore, MD 21287, USA

3. Department of Psychiatry, Johns Hopkins University School of Medicine , Baltimore, MD 21205, USA

4. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205, USA

5. Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205, USA

6. Department of Mental Health, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD, USA

7. Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health , Baltimore, MD 21205, USA

8. Rollins School of Public Health, Emory University , Atlanta, GA 30322, USA

Abstract

Abstract This review article provides a framework for the use of deoxyribonucleic acid (DNA) methylation (DNAm) biomarkers to study the biological embedding of socioeconomic position (SEP) and summarizes the latest developments in the area. It presents the emerging literature showing associations between individual- and neighborhood-level SEP exposures and DNAm across the life course. In contrast to questionnaire-based methods of assessing SEP, we suggest that DNAm biomarkers may offer an accessible metric to study questions about SEP and health outcomes, acting as a personal dosimeter of exposure. However, further work remains in standardizing SEP measures across studies and evaluating consistency across domains, tissue types, and time periods. Meta-analyses of epigenetic associations with SEP are offered as one approach to confirm the replication of DNAm loci across studies. The development of DNAm biomarkers of SEP would provide a method for examining its impact on health outcomes in a more robust way, increasing the rigor of epidemiological studies.

Funder

National Institute of Minority Health and Health Disparities

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Genetics,Molecular Biology

Link

https://academic.oup.com/eep/advance-article-pdf/doi/10.1093/eep/dvac027/47887503/dvac027.pdf

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