Affiliation:
1. Department of Anaesthesiology, West China Hospital, Sichuan University , Chengdu 610041 , China
2. The Research Units of West China (2018RU012)-Chinese Academy of Medical Sciences, West China Hospital, Sichuan University , Chengdu 610041 , China
Abstract
Abstract
Owing to the advances in surgical technology, most solid tumours can be controlled by surgical excision. The priority should be tumour control, while some routine perioperative management might influence cancer progression in an unnoticed way. Moreover, it is increasingly recognized that effective perioperative management should include techniques to improve postoperative outcomes. These influences are elucidated by the different functions of circulating biomarkers in cancer patients. Here, circulating biomarkers with two types of clinical functions were reviewed: (i) circulating biomarkers for cancer progression monitoring, for instance, those related to cancer cell malignancy, tumour microenvironment formation, and early metastasis, and (ii) circulating biomarkers with relevance to postoperative outcomes, including systemic inflammation, immunosuppression, cognitive dysfunction, and pain management. This review aimed to provide new perspectives for the perioperative management of patients with cancer and highlight the potential clinical translation value of circulating biomarkers in improving outcomes.
Funder
National Key Research and Development Program of China
Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences
Publisher
Oxford University Press (OUP)
Reference104 articles.
1. Cancer statistics, 2022;Siegel;CA Cancer J Clin,2022
2. Surgery-mediated tumor-promoting effects on the immune microenvironment;Cheng;Semin Cancer Biol,2022
3. Clinical significance of circulating tumor cells, including cancer stem-like cells, in peripheral blood for recurrence and prognosis in patients with Dukes' stage B and C colorectal cancer;Iinuma;J Clin Oncol,2011
4. Impact of breast cancer surgery on angiogenesis circulating biomarkers: A prospective longitudinal study;Georgiou;World J Surg Oncol,2013
5. Adrenergic, inflammatory, and immune function in the setting of oncological surgery: Their effects on cancer progression and the role of the anesthetic technique in their modulation;Duff;Int Anesthesiol Clin,2016