Analysis of Cyanobacterial Toxins by Physicochemical and Biochemical Methods

Author:

Codd Geoffrey A1,Metcalf James S1,Ward Clive J1,Beattie Kenneth A1,Bell Steven G1,Kaya Kunimitsu2,Poon Grace K3

Affiliation:

1. University of Dundee, Department of Biological Sciences, Dundee DD1 4HN, UK

2. National Institute for Environmental Studies, Environmental Chemistry Division, Tsukuba, Ibaraki 305, Japan

3. Merck Research Laboratories, Drug Metabolism, Rahway, NJ 07065-0900

Abstract

Abstract Cyanobacteria (blue-green algae) produce a wide range of low molecular weight metabolites that include potent neurotoxins, hepatotoxins, and cytotoxins. The accumulation of such toxins in freshwaters, and in brackish and marine waters presents hazards to human and animal health by a range of exposure routes. A review is presented of developments in the detection and analysis of cyanobacterial toxins, other than bioassays, including application of physicochemical, immunoassays, and enzyme-based methods. Analytical requirements are considered with reference to recently derived guideline levels for the protection of health and to the availability, or otherwise, of purified, quantitative cyanobacterial toxin standards.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry

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