Determination of Ephedrine-Type Alkaloids in Dietary Supplements by LC/MS Using a Stable-Isotope Labeled Internal Standard-Reference-Cited by-同舟云学术

Determination of Ephedrine-Type Alkaloids in Dietary Supplements by LC/MS Using a Stable-Isotope Labeled Internal Standard

Published:2001-05-01 Issue:3 Volume:84 Page:761-769
ISSN:1060-3271
Container-title:Journal of AOAC INTERNATIONAL
language:en
Short-container-title:

Author:

Gay Martha L¹,White Kevin D¹,Obermeyer William R²,Betz Joseph M³,Musser Steven M¹

Affiliation:

1. U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Washington, DC 20204

2. ConsumerLab.com, 1234 Rock Hill Rd, Pasadena, MD 21122

3. American Herbal Products Association, 8484 Georgia Ave, Suite 370, Silver Spring, MD

Abstract

Abstract Arapid, isocratic method for the separation of 6 ephedrine-type alkaloids which may occur in dietary supplements was modified to permit quantitation and confirmation by liquid chromatography/mass spectrometry using atmospheric pressure chemical ionization. Several columns and sets of conditions were examined for suitability and the results compared. The use of ion-pairing reagents to enhance resolution is also reported. Mass spectrometric conditions were adjusted to provide sufficient fragmentation for qualitative identification of the analytes. Stable-isotope labeled ephedrine was used as an internal standard for quantitation.

Publisher

Oxford University Press (OUP)

Subject

Pharmacology,Agronomy and Crop Science,Environmental Chemistry,Food Science,Analytical Chemistry

Link

http://academic.oup.com/jaoac/article-pdf/84/3/761/32416042/jaoac0761.pdf

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