Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage-Reference-Cited by-同舟云学术

Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage

Published:2013-11-05 Issue:3 Volume:35 Page:692-702
ISSN:0143-3334
Container-title:Carcinogenesis
language:en
Short-container-title:Carcinogenesis

Author:

Paranjpe A.,Zhang R.,Ali-Osman F.,Bobustuc G. C.,Srivenugopal K. S.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Link

http://academic.oup.com/carcin/article-pdf/35/3/692/7454770/bgt366.pdf

Reference67 articles.

1. Repair of O6-alkylguanine by alkyltransferases

2. Direct Reversal of DNA Alkylation Damage

3. Mechanisms of carcinogenicity/chemotherapy by O6-methylguanine

4. Ubiquitination-Dependent Proteolysis of O6-Methylguanine-DNA Methyltransferase in Human and Murine Tumor Cells following Inactivation with O6-Benzylguanine or 1,3-Bis(2-chloroethyl)-1-nitrosourea

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