Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma

Author:

Zhu Kai12,Zhan Hao1,Peng Yuanfei1,Yang Liuxiao1,Gao Qiang1,Jia Hao3,Dai Zhi1,Tang Zhaoyou1,Fan Jia124,Zhou Jian124

Affiliation:

1. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China

2. Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China

3. Faculty of Basic Medicine, Shanghai Jiaotong University School of Medicine, Shanghai, China

4. Shanghai Key Laboratory of Organ Transplantation, Shanghai, China

Abstract

Abstract Circular RNAs (circRNAs) have recently been identified as a new member of endogenous noncoding RNAs. CircRNAs exhibit high stability and can thus can be used as valuable biomarkers for monitoring the occurrence and development of hepatocellular carcinoma (HCC). The present study sought to explore the diagnostic significance of plasma circRNAs in hepatitis B virus (HBV)-related HCC. Plasma circRNAs from 10 patients with hepatitis B (HBV)-related HCC and 5 patients with HBV-related liver cirrhosis were investigated by microarray to screen differentially expressed circRNAs, 157 upregulated and 161 downregulated circRNAs were found. Twenty-four circRNAs were further investigated via quantitative reverse-transcriptase–polymerase chain reaction assay in a training cohort (n = 48), hsa_circ_0027089 exhibited the highest significance and further distinguished 64 HCC patients from 40 cirrhosis patients and 72 healthy participants in a validation cohort. These results indicate that plasma hsa_circ_0027089 can serve as a new marker for the diagnosis of HBV-related HCC.

Funder

National Natural Science Funds of China

Shanghai Hospital Development Center

National Key Research and Development Program

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

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