The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor-specific genomic imbalances, despite random chromosomal instability

Author:

Wangsa Darawalee1,Braun Rüdiger1,Schiefer Madison1,Gertz Edward Michael2,Bronder Daniel1,Quintanilla Isabel3,Padilla-Nash Hesed M1,Torres Irianna1,Hunn Cynthia1,Warner Lidia1,Buishand Floryne O14,Hu Yue1,Hirsch Daniela5,Gaiser Timo5,Camps Jordi13,Schwartz Russell6,Schäffer Alejandro A2,Heselmeyer-Haddad Kerstin1,Ried Thomas1ORCID

Affiliation:

1. Genetics Branch, Center for Cancer Research, National Cancer Institute/National Institutes of Health, Bethesda, MD, USA

2. Computational Biology Branch, National Center for Biotechnology Information, National Institutes of Health, Bethesda, MD, USA

3. Unitat de Biologia Cellular i Genètica Mèdica, Departament de Biologia Cellular, Fisiologia i Immunologia, Facultat de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain

4. Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands

5. Institute of Pathology, University Medical Center Mannheim, University of Heidelberg, Heidelberg, Germany

6. Departments of Biological Sciences and Computational Biology, Carnegie Mellon University, Pittsburgh, PA, USA

Funder

National Institutes of Health

National Cancer Institute

Pennsylvania Department of Health

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

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