1. Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
2. Pathophysiology and Therapeutics, Hokkaido University Graduate School of Pharmaceutical Science, Sapporo, Japan
3. Department of Internal Medicine, Natsuizaka clinic, Sapporo, Japan
4. Department of Therapeutic Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan
5. Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
6. Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
7. Department of Pathology, Kochi Medical School, Kochi, Japan
8. Gastroenterology Division, University of Pennsylvania, Philadelphia, PA 19104, USA
9. Abramson Cancer Center, Philadelphia, PA 19104, USA