CCL18 promotes migration and invasion of multiple myeloma cells and is associated with poor prognosis

Author:

Qiao Bing1ORCID,Chen Lei1,Cheng Qianwen1,Wang Guangqi1,Li Qun1,Zhang Bo1,Li Junying1,Hu Yu12,Sun Chunyan12

Affiliation:

1. Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, 430022 , China

2. Collaborative Innovation Center of Hematology, Huazhong University of Science and Technology , Wuhan, 430022 , China

Abstract

Abstract CCL18 has recently been implicated in malignancies and is increasingly mentioned as a potential tumoral biomarker and furtherly a molecular target for therapeutic intervention, but its expression and clinical significance in multiple myeloma have not been explored. Serum CCL18 levels were measured by ELISA method in 254 newly diagnosed multiple myeloma (NDMM), 21 monoclonal gammopathy of undetermined significance (MGUS) and 22 healthy adults. The study suggests that the serum CCL18 level in NDMM patients was significantly higher than that in MGUS and healthy adults. High level of CCL18 were associated with advanced ISS and R-ISS stages in MM. Patients with high serum CCL18 displayed a significantly more frequent occurrence of renal impairment and hypercalcemia, while the proportion of achieving complete remission (CR) was lower. More importantly, Cox analysis identified CCL18 and LDH as independent predictors of PFS in MM patients, whereas CCL18, creatinine and LDH were independent predictors of OS. Finally, we show that CCL18 can promote migration and invasion of myeloma cell lines RPMI8226 and MM.1S. CCL18 may play a tumor-promoting role by increasing the migration and invasion abilities of myeloma cells.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference35 articles.

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