Genetic deletion of sphingosine kinase 1 suppresses mouse breast tumor development in an HER2 transgenic model

Author:

Shimizu Yoshiko123,Furuya Hideki12ORCID,Tamashiro Paulette M1,Iino Kayoko1,Chan Owen T M2,Goodison Steve4,Pagano Ian5,Hokutan Kanani23,Peres Rafael2,Loo Lenora W M6,Hernandez Brenda6,Naing Aung7,Chong Clayton D K6,Rosser Charles J2,Kawamori Toshihiko138

Affiliation:

1. Cancer Biology Program, University of Hawaii Cancer Center, Honolulu, HI, USA

2. Clinical and Translational Research Program, University of Hawaii Cancer Center, Honolulu, HI, USA

3. Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, USA

4. Department of Health Sciences Research, Mayo Clinic, Jacksonville, FL, USA

5. Cancer Prevention and Control Program, University of Hawaii Cancer Center, Honolulu, HI, USA

6. Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA

7. Department of Investigational Cancer Therapeutics, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

8. Shonan Medical Clinic, Sonezakishinnchi, Kita-ku, Osaka, Japan

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference51 articles.

1. Cancer statistics, 2016;Siegel;CA. Cancer J. Clin,2016

2. The HER2 receptor in breast cancer: pathophysiology, clinical use, and new advances in therapy;Mitri;Chemother. Res. Pract,2012

3. HER-2/neu amplification predicts poor survival in node-positive breast cancer;Borg;Cancer Res,1990

4. Insights from transgenic mouse models of ERBB2-induced breast cancer;Ursini-Siegel;Nat. Rev. Cancer,2007

5. Prognostic significance of human epidermal growth factor receptor positivity for the development of brain metastasis after newly diagnosed breast cancer;Gabos;J. Clin. Oncol,2006

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