Withaferin A inhibits lysosomal activity to block autophagic flux and induces apoptosis via energetic impairment in breast cancer cells

Author:

Muniraj Nethaji1,Siddharth Sumit1,Nagalingam Arumugam1,Walker Alyssa1,Woo Juhyung1,Győrffy Balázs23,Gabrielson Ed1,Saxena Neeraj K4,Sharma Dipali1

Affiliation:

1. Department of Oncology and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

2. MTA TTK Momentum Cancer Biomarker Research Group, Budapest, Hungary

3. 2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary

4. Early Detection Research Group, National Cancer Institute, Rockville, MD, USA

Funder

National Institutes of Health

Breast Cancer Research Foundation

National Institute of Health National Cancer Institute

The Fetting Fund

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference47 articles.

1. Steroidal lactones from Withania somnifera, an ancient plant for novel medicine;Mirjalili;Molecules,2009

2. Molecular insight in the multifunctional activities of Withaferin A;Vanden Berghe;Biochem. Pharmacol.,2012

3. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review;Mishra;Altern. Med. Rev.,2000

4. Withanolides from Withania somnifera roots;Misra;Phytochemistry,2008

5. Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection;Chaurasiya;Phytochem. Anal.,2008

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