Modeling liver cancer and therapy responsiveness using organoids derived from primary mouse liver tumors

Author:

Cao Wanlu1,Liu Jiaye1,Wang Ling1,Li Meng1,Verstegen Monique M A2,Yin Yuebang1,Ma Buyun1,Chen Kan3,Bolkestein Michiel24,Sprengers Dave1,van der Laan Luc J W2,Doukas Michael5,Kwekkeboom Jaap1,Smits Ron1ORCID,Peppelenbosch Maikel P1ORCID,Pan Qiuwei1

Affiliation:

1. Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands

2. Department of Surgery, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

3. College of Life Sciences, Zhejiang Sci-Tech University, Hangzhou, China

4. Department of Cell Biology, Rotterdam, The Netherlands

5. Department of Pathology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands

Funder

KWF (Dutch Cancer Society) Young Investigator

Daniel den Hoed Foundation Centennial Award fellowship

China Scholarship Council PhD fellowships

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference26 articles.

1. Sorafenib in advanced hepatocellular carcinoma;Llovet;N. Engl. J. Med,2008

2. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models;Voskoglou-Nomikos;Clin. Cancer Res,2003

3. Hepatocellular carcinoma;Llovet;Nat. Rev. Dis. Primers,2016

4. Histological organization in hepatocyte organoid cultures;Michalopoulos;Am. J. Pathol,2001

5. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration;Huch;Nature,2013

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