Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis

Author:

Park Seok Soon123,Lee Dong Min124,Lim Jun Hee4,Lee Dongjoo5,Park Sang Jun6,Kim Hwan Myung6,Sohn Seonghyang7,Yoon Gyesoon12,Eom Young Woo8,Jeong Seong-Yun3,Choi Eun Kyung9,Choi Kyeong Sook124

Affiliation:

1. Department of Biochemistry, Ajou University School of Medicine, Suwon, Korea

2. Department of Biomedical Sciences, Ajou Graduate School, Suwon, Korea

3. Asan Institute for Life Sciences, Department of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

4. Genomic Instability Center, Ajou University School of Medicine, Suwon, Korea

5. Department of Pharmacy, Ajou University, Suwon, Korea

6. Department of Energy Systems Research, Ajou University, Suwon, Korea

7. Department of Microbiology, Ajou University, Suwon, Korea

8. Cell therapy and Tissue Engineering Center, Wonju College of Medicine, Yonsei University, Wonju, Korea

9. Center for Advancing Cancer Therapeutics, Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea

Funder

National Research Foundation of Korea

Ministry of Health and Welfare

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference55 articles.

1. Epidemiology of viral hepatitis and hepatocellular carcinoma;El-Serag;Gastroenterology,2012

2. Treatment modalities for hepatocellular carcinoma;Hung;Curr. Cancer Drug Targets,2005

3. Prospective cohort study of transarterial chemoembolization for unresectable hepatocellular carcinoma in 8510 patients;Takayasu;Gastroenterology,2006

4. Transcatheter arterial chemoembolization for liver cancer: is it time to distinguish conventional from drug-eluting chemoembolization;Liapi;Cardiovasc. Intervent. Radiol,2011

5. Oxygen-dependent hepatotoxicity due to doxorubicin: role of reducing equivalent supply in perfused rat liver;Ganey;Mol. Pharmacol,1988

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