Affiliation:
1. Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Easter Bush , Midlothian EH25 9RG , UK
Abstract
Abstract
Background
Staphylococcus pseudintermedius is a common opportunistic pathogen of companion dogs and an occasional human pathogen. Treatment is hampered by antimicrobial resistance including methicillin resistance encoded by mecA within the mobile genetic element SCCmec.
Objectives
SCCmec elements are diverse, especially in non-Staphyloccocus aureus staphylococci, and novel variants are likely to be present in S. pseudintermedius. The aim was to characterize the SCCmec elements found in four canine clinical isolates of S. pseudintermedius.
Material and methods
Isolates were whole-genome sequenced and SCCmec elements were assembled, annotated and compared to known SCCmec types.
Results and discussion
Two novel SSCmec are present in these isolates. SCCmec7017-61515 is characterized by a novel combination of a Class A mec gene complex and a type 5 ccr previously only described in composite SCCmec elements. The other three isolates share a novel composite SCCmec with features of SCCmec types IV and VI.
Conclusions
S. pseudintermedius is a reservoir of novel SSCmec elements that has implications for understanding antimicrobial resistant in veterinary and human medicine.
Publisher
Oxford University Press (OUP)
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