Forensic features and phylogenetic structure survey of four populations from southwest China via the autosomal insertion/deletion markers

Author:

Zhang Han12,Yang Meiqing1,Zhang Hongling1,Ren Zheng1,Wang Qiyan1,Liu Yubo1,Jin Xiaoye1,Ji Jingyan1,Feng Yuhang1,Cai Changsheng1,Ran Qianchong1,Li Chengtao2,Huang Jiang34

Affiliation:

1. Department of Forensic Medicine, Guizhou Medical University , Guiyang, Guizhou, China

2. Institute of Forensic Science , Fudan University, Shanghai, China

3. The Key Laboratory of Environmental Pollution Monitoring and Disease Control , Ministry of Education, , Guiyang, China

4. Guizhou Medical University , Ministry of Education, , Guiyang, China

Abstract

Abstract   Insertion/Deletion (InDel) polymorphisms, characterized by their smaller amplicons, reduced mutation rates, and compatibility with the prevalent capillary electrophoresis (CE) platforms in forensic laboratories, significantly contribute to the advancement and application of genetic analysis. Guizhou province in China serves as an important region for investigating the genetic structure, ethnic group origins, and human evolution. However, DNA data and the sampling of present-day populations are lacking, especially about the InDel markers. Here, we reported data on 47 autosomal InDels from 592 individuals from four populations in Guizhou (Han, Dong, Yi, and Chuanqing). Genotyping was performed with the AGCU InDel 50 kit to evaluate their utility for forensic purposes and to explore the population genetic structure. Our findings showed no significant deviations from Hardy-Weinberg and linkage equilibriums. The combined power of discrimination (CPD) and the combined power of exclusion (CPE) for each population demonstrated that the kit could be applied to forensic individual identification and was an effective supplement for parentage testing. Genetic structure analyses, including principal component analysis, multidimensional scaling, genetic distance calculation, STRUCTURE, and phylogenetic analysis, highlighted that the genetic proximity of the studied populations correlates with linguistic, geographical, and cultural factors. The observed genetic variances within four research populations were less pronounced than those discerned between populations across different regions. Notably, the Guizhou Han, Dong, and Chuanqing populations showed closer genetic affiliations with linguistically similar groups than the Guizhou Yi. These results underscore the potential of InDel markers in forensic science and provide insights into the genetic landscape and human evolution in multi-ethnic regions like Guizhou. Key points

Funder

National Natural Science Foundation of China

Guizhou Province Education Department, Characteristic Region Project, Qian Education

Guizhou Province Engineering Technology Research Center Project

Qian Science Talent Platform

Guizhou Scientific Support Project

Guizhou Science Project

Guizhou Medical University Academic Sprout Cultivation Project

Opening Foundation of Shanghai Key Lab of Forensic Medicine

Key Lab of Forensic Science

Ministry of Justice, China

Guizhou Innovation Training Program for College Students

Publisher

Oxford University Press (OUP)

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