Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses-Reference-Cited by-同舟云学术

Aviremia 10 Years Postdiscontinuation of Antiretroviral Therapy Initiated During Primary Human Immunodeficiency Virus-1 Infection and Association With Gag-Specific T-Cell Responses

Published:2015 Issue:4 Volume:2 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Kinloch-de Loes Sabine¹²³,Dorrell Lucy⁴⁵,Yang Hongbing⁴⁵,Hardy Gareth A. D.⁶⁷,Yerly Sabine⁸,Cellerai Cristina¹⁹,Vandekerckhove Linos¹⁰¹¹,De Spielgelaere Ward¹⁰¹¹,Malatinkova Eva¹⁰¹¹,Wee Lee Koh Willie¹²,Johnson Margaret A.¹²

Affiliation:

1. Division of Infection and Immunity, Royal Free Campus, University College London

2. Royal Free Hospital, London

3. Department of Immunology, University College London Medical School, Royal Free Campus

4. Nuffield Department of Medicine

5. Oxford National Institute of Health Research Biomedical Research Centre, University of Oxford

6. Centre for Immunology and Virology, Imperial College London

7. Chelsea and Westminster Hospital, London, United Kingdom

8. Laboratory of Virology, Geneva University Hospital

9. Division of Immunology and Allergy, Department of Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

10. HIV Translational Research Unit, Ghent University

11. University Hospital Ghent, Belgium

12. Department of Immunology and Molecular Pathology, University College London Medical School, University College London Campus, United Kingdom

Abstract

Abstract Combination antiretroviral therapy during primary human immunodeficiency virus-1 infection may enable long-term drug-free virological control in rare individuals. We describe a female who maintained aviremia and a normal CD4+/CD8+ T cell ratio for 10 years after stopping therapy, despite a persistent viral reservoir. Cellular immune responses may have contributed to this outcome.

Funder

Oxford NIHR Biomedical Research Centre

Agency for Innovation by Science and Technology of the Flemish Government

FWO

HIV-ERA

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/2/4/ofv144/33602212/ofv144.pdf

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