Necrotizing Fasciitis in Hematological Patients: Enterobacteriaceae Predominance and Limited Utility of Laboratory Risk Indicator for Necrotizing Fasciitis Score

Author:

Foo Rui Min1,Tung Moon Ley2,Poon Li Mei2,Chan Douglas3,Smitasin Nares1,Koh Liang Piu2,Chng Wee Joo245,Chai Louis Yi Ann1

Affiliation:

1. Division of Infectious Diseases, University Medicine Cluster, National University Health System, Singapore

2. Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System

3. Department of Laboratory Medicine, National University Hospital, Singapore

4. Faculty of Medicine, Yong Loo Lin School of Medicine, National University of Singapore

5. Cancer Science Institute of Singapore, National University of Singapore

Abstract

Immune suppression is a recognized risk factor for necrotizing fasciitis. In patients with hematological malignancies, a profoundly immunocompromised group, the predominant causative organisms are Gram negative. Clinical presentation and outcomes in these patients are similar to the immunocompetent. The Laboratory Risk Indicator for Necrotizing Fasciitis score is not reliable for risk stratification of the disease.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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