In-Hospital Pneumococcal Polysaccharide Vaccination Is Associated With Detection of Pneumococcal Vaccine Serotypes in Adults Hospitalized for Community-Acquired Pneumonia

Author:

Grijalva Carlos G.12,Wunderink Richard G.3,Zhu Yuwei1,Williams Derek J.1,Balk Robert4,Fakhran Sherene5,Courtney D. Mark3,Anderson Evan J.6,Qi Chao3,Trabue Christopher7,Pavia Andrew T.8,Moore Matthew R.9,Jain Seema9,Edwards Kathryn M.1,Self Wesley H.1

Affiliation:

1. Vanderbilt University School of Medicine, Nashville, Tennessee

2. Geriatric Research Education Clinical Center, VA Tennessee Valley, Nashville

3. Northwestern University-Feinberg School of Medicine

4. Rush University School of Medicine

5. John H. Stroger, Jr. Hospital of Cook County, Chicago, Illinois

6. Emory University School of Medicine, Atlanta, Georgia

7. University of Tennessee Health Science Center/Saint Thomas Health, Nashville

8. University of Utah School of Medicine, Salt Lake City

9. Centers for Disease Control and Prevention, Atlanta, Georgia

Abstract

Abstract During an etiology study of adults hospitalized for pneumonia, in which urine specimens were examined for serotype-specific pneumococcal antigen detection, we observed that some patients received 23-valent pneumococcal polysaccharide vaccine before urine collection. Some urine samples became positive for specific vaccine pneumococcal serotypes shortly after vaccination, suggesting false-positive test results.

Funder

National Center for Immunization and Respiratory Diseases

Centers for Disease Control and Prevention

Agency for Healthcare Research and Quality

National Institute of Allergy and Infectious Diseases

National Institutes of Health

NIH

National Institute of General Medical Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference15 articles.

1. Effect of use of 13-valent pneumococcal conjugate vaccine in children on invasive pneumococcal disease in children and adults in the USA: analysis of multisite, population-based surveillance;Moore;Lancet Infect Dis,2015

2. U.S. Hospitalizations for pneumonia after a decade of pneumococcal vaccination;Griffin;N Engl J Med,2013

3. Decline in pneumonia admissions after routine childhood immunisation with pneumococcal conjugate vaccine in the USA: a time-series analysis;Grijalva;Lancet,2007

4. Use of 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine among adults aged ≥65 years: recommendations of the Advisory Committee on Immunization Practices (ACIP);Tomczyk;MMWR Morb Mortal Wkly Rep,2014

5. Community-acquired pneumonia requiring hospitalization among U.S. adults;Jain;N Engl J Med,2015

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