Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study
Author:
Vanhommerig Joost W.12, Lambers Femke A. E.1, Schinkel Janke2, Geskus Ronald B.13, Arends Joop E.4, van de Laar Thijs J. W.5, Lauw Fanny N.6, Brinkman Kees7, Gras Luuk8, Rijnders Bart J. A.9, van der Meer Jan T. M.10, Prins Maria110, van der Meer J.T.M., Molenkamp R., Mutschelknauss M., Nobel H.E., Reesink H.W., Schinkel J., van der Valk M., van den Berk G.E.L., Brinkman K., Kwa D., van der Meche N., Toonen A., Vos D., van Broekhuizen M., Lauw F.N., Mulder J.W., Arends J.E., van Kessel A., de Kroon I., Boonstra A., van der Ende M.E., Hullegie S., Rijnders B.J.A., van de Laar T.J.W., Gras L., Smit C., Lambers F.A.E., Prins M., Vanhommerig J.W., van der Veldt W.,
Affiliation:
1. Department of Infectious Diseases, Public Health Service of Amsterdam 2. Departments of Medical Microbiology 3. Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, Amsterdam 4. Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht 5. Department of Blood-Borne Infections, Sanquin Blood Supply Foundation, Amsterdam 6. Department of Internal Medicine, Slotervaart Hospital, Amsterdam 7. Department of Internal Medicine, OLVG Hospital, Amsterdam 8. HIV Monitoring Foundation, Amsterdam 9. Department of Internal Medicine and Infectious Diseases, Erasmus University Medical Center, Rotterdam 10. Department of Internal Medicine, Center of Infectious Diseases and Immunology Amsterdam, Academic Medical Center, The Netherlands
Abstract
AbstractBackground. Since 2000, incidence of sexually acquired hepatitis C virus (HCV)-infection has increased among human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). To date, few case-control and cohort studies evaluating HCV transmission risk factors were conducted in this population, and most of these studies were initially designed to study HIV-related risk behavior and characteristics.Methods. From 2009 onwards, HIV-infected MSM with acute HCV infection and controls (HIV-monoinfected MSM) were prospectively included in the MOSAIC (MSM Observational Study of Acute Infection with hepatitis C) study at 5 large HIV outpatient clinics in the Netherlands. Written questionnaires were administered, covering sociodemographics, bloodborne risk factors for HCV infection, sexual behavior, and drug use. Clinical data were acquired through linkage with databases from the Dutch HIV Monitoring Foundation. For this study, determinants of HCV acquisition collected at the inclusion visit were analyzed using logistic regression.Results. Two hundred thirteen HIV-infected MSM (82 MSM with acute HCV infection and 131 MSM without) were included with a median age of 45.7 years (interquartile range [IQR], 41.0–52.2). Receptive unprotected anal intercourse (adjusted odds ratio [aOR], 5.01; 95% confidence interval [CI], 1.63–15.4), sharing sex toys (aOR, 3.62; 95% CI, 1.04–12.5), unprotected fisting (aOR, 2.57; 95% CI, 1.02–6.44), injecting drugs (aOR, 15.62; 95% CI, 1.27–192.6), sharing straws when snorting drugs (aOR, 3.40; 95% CI, 1.39–8.32), lower CD4 cell count (aOR, 1.75 per cubic root; 95% CI, 1.19–2.58), and recent diagnosis of ulcerative sexually transmitted infection (aOR, 4.82; 95% CI, 1.60–14.53) had significant effects on HCV acquisition.Conclusions. In this study, both sexual behavior and biological factors appear to independently increase the risk of HCV acquisition among HIV-infected MSM.
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
80 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|