Rethinking Risk for Pneumococcal Disease in Adults: The Role of Risk Stacking

Author:

Pelton Stephen I.12,Shea Kimberly M.1,Weycker Derek3,Farkouh Raymond A.4,Strutton David R.4,Edelsberg John3

Affiliation:

1. Boston University Schools of Medicine and Public Health

2. Boston Medical Center

3. Policy Analysis Inc., Brookline, Massachusetts

4. Pfizer Inc., Collegeville, Pennsylvania

Abstract

Abstract Using data from 3 private healthcare claims repositories, we evaluated the incidence of pneumococcal disease among adults with US Advisory Committee on Immunization Practices (ACIP) defined at-risk conditions or rheumatoid arthritis, lupus, Crohn's disease, and neuromuscular disorder/seizures and those with traditional high-risk conditions. We observed that adults with ≥2 concurrent comorbid conditions had pneumococcal disease incidence rates that were as high as or higher than rates observed in those with traditional high-risk conditions.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Reference13 articles.

1. Rates of pneumococcal disease in adults with chronic medical conditions;Shea;Open Forum Infect Dis,2014

2. Use of 13-Valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine for adults with immunocompromising conditions: recommendations of the Advisory Committee on Immunization Practices (ACIP);Centers for Disease Control and Prevention (CDC);MMWR Morb Mortal Wkly Rep,2012

3. Risk of pneumococcal disease in children with chronic medical conditions in the era of pneumococcal conjugate vaccine;Pelton;Clin Infect Dis,2014

4. Distribution of 13-valent pneumococcal conjugate vaccine Streptococcus pneumoniae serotypes in US adults aged ≥50 years with community-acquired pneumonia;Sherwin;J Infect Dis,2013

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