CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean-Reference-Cited by-同舟云学术

CD4 Response Up to 5 Years After Combination Antiretroviral Therapy in Human Immunodeficiency Virus-Infected Patients in Latin America and the Caribbean

Published:2015-04-01 Issue:2 Volume:2 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Luz Paula M.¹,Belaunzarán-Zamudio Pablo F.²,Crabtree-Ramírez Brenda²,Caro-Vega Yanink²,Hoces Daniel³,Rebeiro Peter F.⁴,Blevins Meridith⁴,Pape Jean W.⁵,Cortes Claudia P.⁶,Padgett Denis⁷,Cahn Pedro⁸,Veloso Valdilea G.¹,McGowan Catherine C.⁴,Grinsztejn Beatriz¹,Shepherd Bryan E.⁴,

Affiliation:

1. Fundação Oswaldo Cruz, Instituto de Nacional de Infectologia Evandro Chagas, Rio de Janeiro, Brazil

2. Department of Infectious Diseases, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

3. Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru

4. Vanderbilt University School of Medicine, Nashville, Tennessee

5. Division of Infectious Diseases, Department of Medicine, Weill Cornell Medical College, New York

6. School of Medicine, University of Chile, Santiago

7. Universidad Nacional Autónoma de Honduras, Tegucigalpa

8. Fundación Huesped, Buenos Aires, Argentina

Abstract

We describe CD4 counts at 6-month intervals for 5 years after combination antiretroviral therapy initiation among 12 879 antiretroviral-naive human immunodeficiency virus-infected adults from Latin America and the Caribbean. Median CD4 counts increased from 154 cells/mm3 at baseline (interquartile range [IQR], 60–251) to 413 cells/mm3 (IQR, 234–598) by year 5.

Funder

the National Institute of Allergy and Infectious Diseases as part of the International Epidemiologic Databases to Evaluate AIDS

the National Council of Technological and Scie.jpegic Development

the Research Funding Agency of the State of Rio de Janeiro

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

http://academic.oup.com/ofid/article-pdf/2/2/ofv079/33621099/ofv079.pdf

Reference14 articles.

1. Efficacy and safety of three antiretroviral regimens for initial treatment of HIV-1: a randomized clinical trial in diverse multinational settings;Campbell;PLoS Med,2012