1. Department of Translational Medicine, Università del Piemonte Orientale , Via Solaroli 18, Novara, 28100 , Italy
2. Internal Medicine, Ospedale degli Infermi , Ponderano, Via dei Ponderanesi 2, Biella, 13875 , Italy
3. Emergency Department, Ospedale degli Infermi , Ponderano, Via dei Ponderanesi 2, Biella, 13875 , Italy
4. Epidemiology Centre of Local Health Unit of Vercelli , Largo Giusti 13, Vercelli, 13100 , Italy
5. Institute of Clinical Trials and Methodology, Faculty of Population Health Sciences, University College London , 90 High Holborn, London WC1V 6LJ , UK
6. British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB , UK