A common data model for the standardization of intensive care unit medication features

Author:

Sikora Andrea1ORCID,Keats Kelli2,Murphy David J3,Devlin John W45,Smith Susan E6,Murray Brian7,Buckley Mitchell S8ORCID,Rowe Sandra9,Coppiano Lindsey1011,Kamaleswaran Rishikesan1011

Affiliation:

1. Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy , Augusta, GA 30912, United States

2. Department of Pharmacy, Augusta University Medical Center , Augusta, GA 30912, United States

3. Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Emory University , Atlanta, GA 30322, United States

4. Northeastern University School of Pharmacy , Boston, MA 02115, United States

5. Division of Pulmonary and Critical Care Medicine, Brigham and Women’s Hospital , Boston, MA 02115, United States

6. Department of Clinical and Administrative Pharmacy, University of Georgia College of Pharmacy , Athens, GA 30601, United States

7. Department of Pharmacy, University of North Carolina Medical Center , Chapel Hill, NC 27514, United States

8. Department of Pharmacy, Banner University Medical Center Phoenix , Phoenix, AZ 85032, United States

9. Department of Pharmacy, Oregon Health and Science University , Portland, OR 97239, United States

10. Department of Biomedical Informatics, Emory University School of Medicine , Atlanta, GA 30322, United States

11. Department of Biomedical Engineering, Georgia Institute of Technology , Atlanta, GA 30322, United States

Abstract

Abstract Objective Common data models provide a standard means of describing data for artificial intelligence (AI) applications, but this process has never been undertaken for medications used in the intensive care unit (ICU). We sought to develop a common data model (CDM) for ICU medications to standardize the medication features needed to support future ICU AI efforts. Materials and Methods A 9-member, multi-professional team of ICU clinicians and AI experts conducted a 5-round modified Delphi process employing conference calls, web-based communication, and electronic surveys to define the most important medication features for AI efforts. Candidate ICU medication features were generated through group discussion and then independently scored by each team member based on relevance to ICU clinical decision-making and feasibility for collection and coding. A key consideration was to ensure the final ontology both distinguished unique medications and met Findable, Accessible, Interoperable, and Reusable (FAIR) guiding principles. Results Using a list of 889 ICU medications, the team initially generated 106 different medication features, and 71 were ranked as being core features for the CDM. Through this process, 106 medication features were assigned to 2 key feature domains: drug product-related (n = 43) and clinical practice-related (n = 63). Each feature included a standardized definition and suggested response values housed in the electronic data library. This CDM for ICU medications is available online. Conclusion The CDM for ICU medications represents an important first step for the research community focused on exploring how AI can improve patient outcomes and will require ongoing engagement and refinement.

Funder

Agency of Healthcare Research and Quality

Publisher

Oxford University Press (OUP)

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