TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining-Reference-Cited by-同舟云学术

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining

Published:2018-08-03 Issue:17 Volume:46 Page:8926-8939
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Kawale Ajinkya S¹,Akopiants Konstantin¹,Valerie Kristoffer²,Ruis Brian³,Hendrickson Eric A³,Huang Shar-yin N⁴,Pommier Yves⁴,Povirk Lawrence F¹^ORCID

Affiliation:

1. Department of Pharmacology and Toxicology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA

2. Department of Radiation Oncology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA

3. Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota Medical School, Minneapolis, MN 55455, USA

4. Developmental Therapeutics Branch and Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Building 37, Room 5068, Bethesda, MD 20892-4255, USA

Funder

National Institutes of Health

NCI-NIH intramural research program

NIH-NINDS Center core

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/46/17/8926/25843342/gky694.pdf

Reference44 articles.

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2. The crystal structure of human tyrosyl-DNA phosphodiesterase, Tdp1;Davies;Structure,2002

3. Yeast gene for a tyr-DNA phosphodiesterase that repairs topoisomerase I complexes;Pouliot;Science,1999

4. Mutation of TDP1, encoding a topoisomerase i–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy;Takashima;Nat. Genet.,2002

5. Tyrosyl-DNA phosphodiesterases: Rescuing the genome from the risks of relaxation;Kawale;Nucleic Acids Res.,2018

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