The Who, What, When, and Where of Inpatient Direct Oral Penicillin Challenge—Implications for Health Services Implementation

Author:

Trubiano Jason Anthony12ORCID,Vogrin Sara12,Mitri Elise123,Hall Rebecca1,Copaescu Ana124,Waldron Jamie1,De Luca Joseph1,Rose Morgan125,Mackay Geoff6,Lambros Belinda5,Douglas Abby P157,Holmes Natasha E128,Chua Kyra Y L1

Affiliation:

1. Department of Infectious Diseases, Centre for Antibiotic Allergy and Research, Austin Health , Heidelberg, Victoria , Australia

2. Department of Infectious Diseases, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity , Melbourne, Victoria , Australia

3. Department of Pharmacy, Austin Health , Heidelberg, Victoria , Australia

4. Department of Medicine, Division of Allergy and Clinical Immunology, McGill University Health Center , Montreal, Quebec , Canada

5. Department of Infectious Diseases, The National Centre for Infections in Cancer, Peter MacCallum Cancer Centre , Parkville, VIC , Australia

6. Albury Wodonga Health , Albury, New South Wales , Australia

7. Sir Peter MacCallum Department of Oncology, University of Melbourne , Parkville, Victoria , Australia

8. Data Analytics Research and Evaluation (DARE) Centre, Austin Health and The University of Melbourne , Heidelberg, Victoria , Australia

Abstract

AbstractInpatient direct oral challenge programs are increasingly deployed as part of antimicrobial stewardship initiatives to reduce the burden and impacts of penicillin allergy labels on antibiotic prescribing. Using data from a prospective, multicenter cohort inpatient penicillin allergy program, we identify the key targets for delabeling to aid health service implementation.

Funder

Better Care Victoria Innovation Fund

National Health and Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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