Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique-Reference-Cited by-同舟云学术

Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique

Published:2023-12-04 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Mariner-Llicer Carla¹^ORCID,Saavedra Cervera Belén²³^ORCID,Mambuque Edson³^ORCID,Gomes Neide³,Munguambe Shilzia³,Villamayor Luis⁴,Cancino-Muñoz Irving⁴⁵^ORCID,Torres-Puente Manuela¹^ORCID,Nguenha Dinis³⁶^ORCID,Respeito Durval³,Tembe Gustavo³^ORCID,López Mariana G¹^ORCID,Comas Iñaki¹⁷^ORCID,García-Basteiro Alberto L²³⁸^ORCID

Affiliation:

1. Tuberculosis Genomics Unit, Instituto de Biomedicina de Valencia (IBV), CSIC , Valencia , Spain

2. ISGlobal, Hospital Clínic – Universitat de Barcelona , Barcelona , Spain

3. Centro de Investigação em Saúde de Manhiça (CISM) , Maputo , Mozambique

4. FISABIO Public Health , Valencia , Spain

5. I2SysBio, Universitat de València CSIC , Valencia , Spain

6. Amsterdam Institute for Global Health & Development (AIGHD) , Amsterdam , The Netherlands

7. CIBER in Epidemiology and Public Health , Madrid , Spain

8. Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC) , Barcelona , Spain

Abstract

Abstract Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate detection of antimicrobial-resistance in the country.

Funder

National Institutes of Health

Spanish Ministry of Science and Innovation

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciad684/53970124/ciad684.pdf

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