Priorities and Progress in Gram-positive Bacterial Infection Research by the Antibacterial Resistance Leadership Group: A Narrative Review

Author:

Doernberg Sarah B1ORCID,Arias Cesar A234,Altman Deena R56,Babiker Ahmed78,Boucher Helen W9,Creech C Buddy1011,Cosgrove Sara E12,Evans Scott R13,Fowler Vance G14,Fritz Stephanie A15,Hamasaki Toshimitsu16,Kelly Brendan J17,Leal Sixto M18,Liu Catherine1920,Lodise Thomas P21,Miller Loren G2223,Munita Jose M2425,Murray Barbara E26,Pettigrew Melinda M27,Ruffin Felicia14,Scheetz Marc H28,Shopsin Bo2930,Tran Truc T3,Turner Nicholas A14,Williams Derek J31,Zaharoff Smitha32,Holland Thomas L14,Patel Robin,King Heather,Kinamon Tori,Dai Weixiao,Geres Holly,Deckard Nancie,Schuler Carl,Bunn Ivra,Sharma Shrabani,Wickward Cathy,Waller Jason,Wilson Holly,Mehigan Maureen,Ghazaryan Varduhi,Raterman Erica,Samuel Tamika,Lee Marina,

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, University of California, SanFrancisco , California , USA

2. Division of Infectious Diseases, Department of Medicine, Houston Methodist Hospital , Houston, Texas , USA

3. Center for Infectious Diseases, Houston Methodist Research Institute , Houston, Texas , USA

4. Department of Medicine, Weill-Cornell Medical College , New York, New York , USA

5. Division of Infectious Diseases, Department of Medicine , Icahn School of Medicine at Mount Sinai, New York, New York , USA

6. Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai , NewYork, New York , USA

7. Division of Infectious Diseases, Department of Medicine , Emory University School of Medicine, Atlanta, Georgia , USA

8. Department of Pathology and Laboratory Medicine, Emory University School of Medicine , Atlanta, Georgia , USA

9. Tufts University School of Medicine , Medford, Massachusetts , USA

10. Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University School of Medicine , Nashville, Tennessee , USA

11. Vanderbilt Vaccine Research Program, Vanderbilt University Medical Center , Nashville, Tennessee , USA

12. Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

13. Department of Biostatistics, George Washington University , Washington, District of Columbia , USA

14. Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine , Durham, North Carolina , USA

15. Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine , St Louis, Missouri , USA

16. Biostatistics Center, George Washington University , Rockville, Maryland , USA

17. Division of Infectious Diseases, Department of Medicine, Perelman School of Medicine, University of Pennsylvania , Philadelphia, Pennsylvania , USA

18. Department of Laboratory Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA

19. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

20. Division of Allergy and Infectious Diseases, University of Washington , Seattle, Washington , USA

21. Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences , Albany, New York , USA

22. Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles , California , USA

23. Division of Infectious Diseases, Lundquist Institute at Harbor-UCLA Medical Center , Torrance, California , USA

24. Instituto de Ciencias e Innovación en Medicina, Facultad de Medicina Clinica Alemana, Universidad del Desarrollo , Santiago, Chile

25. Multidisciplinary Initiative for Collaborative Research on Bacterial Resistance , Santiago , Chile

26. Division of Infectious Diseases, Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center at Houston , Houston, Texas , USA

27. Department of Epidemiology of Microbial Diseases, Yale School of Public Health , New Haven, Connecticut , USA

28. Pharmacometrics Center of Excellence, College of Pharmacy, Midwestern University , Downers Grove, Illinois , USA

29. Division of Infectious Diseases, Department of Medicine , New York University Grossman School of Medicine, New York, New York , USA

30. Department of Microbiology, NewYork University Grossman School of Medicine , New York, New York , USA

31. Division of Hospital Medicine, Department of Pediatrics, Vanderbilt University School of Medicine and the Monroe Carell Jr Children's Hospital at Vanderbilt University Medical Center , Nashville, Tennessee , USA

32. Duke Clinical Research Institute, Duke University School of Medicine , Durham, North Carolina , USA

Abstract

AbstractThe Antibacterial Resistance Leadership Group (ARLG) has prioritized infections caused by gram-positive bacteria as one of its core areas of emphasis. The ARLG Gram-positive Committee has focused on studies responding to 3 main identified research priorities: (1) investigation of strategies or therapies for infections predominantly caused by gram-positive bacteria, (2) evaluation of the efficacy of novel agents for infections caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci, and (3) optimization of dosing and duration of antimicrobial agents for gram-positive infections. Herein, we summarize ARLG accomplishments in gram-positive bacterial infection research, including studies aiming to (1) inform optimal vancomycin dosing, (2) determine the role of dalbavancin in MRSA bloodstream infection, (3) characterize enterococcal bloodstream infections, (4) demonstrate the benefits of short-course therapy for pediatric community-acquired pneumonia, (5) develop quality of life measures for use in clinical trials, and (6) advance understanding of the microbiome. Future studies will incorporate innovative methodologies with a focus on interventional clinical trials that have the potential to change clinical practice for difficult-to-treat infections, such as MRSA bloodstream infections.

Funder

National Institute of Allergy and Infectious Diseases

(NIAID)

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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