Immunogenicity of the BA.1 and BA.4/BA.5 Severe Acute Respiratory Syndrome Coronavirus 2 Bivalent Boosts: Preliminary Results From the COVAIL Randomized Clinical Trial

Author:

Branche Angela R1,Rouphael Nadine G2ORCID,Losada Cecilia2,Baden Lindsey R3,Anderson Evan J4,Luetkemeyer Anne F5,Diemert David J6ORCID,Winokur Patricia L7,Presti Rachel M8,Kottkamp Angelica C9,Falsey Ann R1,Frey Sharon E10,Rupp Richard11,Bäcker Martín12,Novak Richard M13,Walter Emmanuel B14,Jackson Lisa A15,Little Susan J16,Immergluck Lilly C17,Mahgoub Siham M18,Whitaker Jennifer A19,Babu Tara M20,Goepfert Paul A21,Fusco Dahlene N22,Atmar Robert L19,Posavad Christine M23,Netzl Antonia24,Smith Derek J24,Telu Kalyani25,Mu Jinjian25,Makowski Mat25,Makhene Mamodikoe K26,Crandon Sonja26,Montefiori David C27,Roberts Paul C26,Beigel John H26

Affiliation:

1. Department of Medicine, University of Rochester VTEU , Rochester, New York , USA

2. Department of Medicine, Emory University Hope Clinic , Decatur, Georgia , USA

3. Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

4. Center for Childhood Infections and Vaccines (CCIV) of Children's Healthcare of Atlanta and Emory University Department of Pediatrics , Atlanta, Georgia , USA

5. Zuckerberg San Francisco General, University of California San Francisco , San Francisco, California , USA

6. George Washington Vaccine Research Unit, George Washington University , Washington DC , USA

7. Department of Medicine, University of Iowa College of Medicine , Iowa City, Iowa , USA

8. Department of Medicine, Washington University School of Medicine , St. Louis, Missouri , USA

9. Department of Medicine, New York University (NYU) Vaccine and Treatment Evaluation Unit (VTEU) Manhattan Research Clinic at NYU Grossman School of Medicine , New York, New York , USA

10. Saint Louis University , Center for Vaccine Development, St. Louis, Missouri , USA

11. Department of Pediatrics, University of Texas Medical Branch , Galveston, Texas , USA

12. Department of Medicine, NYU VTEU Long Island Research Clinic at NYU Long Island School of Medicine , Mineola, New York , USA

13. Department of Medicine, University of Illinois at Chicago-Project WISH , Chicago, Illinois , USA

14. Department of Pediatrics, Duke Human Vaccine Institute, Duke University School of Medicine , Durham, North Carolina , USA

15. Kaiser Permanente Washington Health Research Institute , Seattle, Washington , USA

16. Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, California , USA

17. Department of Microbiology/Biochemistry/Immunology, Morehouse School of Medicine , Atlanta, Georgia , USA

18. Department of Medicine, Howard University College of Medicine, Howard University Hospital , Washington DC , USA

19. Departments of Molecular Virology and Microbiology and Medicine , Baylor College of Medicine, Houston, Texas , USA

20. Departments of Medicine, Epidemiology, and Laboratory Medicine & Pathology, University of Washington , Vaccines and Infectious Diseases Division, Fred Hutchinson Cancer Center, Seattle, Washington , USA

21. Department of Medicine, University of Alabama at Birmingham , Birmingham, Alabama , USA

22. Department of Medicine, Tulane University School of Medicine , New Orleans, Louisiana , USA

23. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center and Department of Laboratory Medicine and Pathology, University of Washington , Seattle, Washington , USA

24. Centre for Pathogen Evolution, Department of Zoology, University of Cambridge , Cambridge , United Kingdom

25. The Emmes Company, LLC , Rockville, Maryland , USA

26. Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health , Bethesda, Maryland , USA

27. Department of Surgery, Duke University , Durham, North Carolina , USA

Abstract

Abstract In a randomized clinical trial, we compare early neutralizing antibody responses after boosting with bivalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) messenger RNA (mRNA) vaccines based on either BA.1 or BA.4/BA.5 Omicron spike protein combined with wild-type spike. Responses against SARS-CoV-2 variants exhibited the greatest reduction in titers against currently circulating Omicron subvariants for both bivalent vaccines.

Funder

National Cancer Institute

National Institutes of Health

Department of Health and Human Services

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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