Adult Cerebral Malaria: Acute and Subacute Imaging Findings, Long-term Clinical Consequences

Author:

Coughlan Charles1ORCID,Jäger Hans Rolf234,Brealey David5,Carletti Francesco23ORCID,Hyare Harpreet2ORCID,Pattnaik Rajyabardhan6,Sahu Praveen K7,Mohanty Sanjib7,Logan Sarah1,Hoffmann Angelika8,Wassmer Samuel C9ORCID,Checkley Anna M19

Affiliation:

1. Department of Infectious Diseses, University College London Hospitals NHS Foundation Trust , London , United Kingdom

2. Department of Radiology, University College London Hospitals NHS Foundation Trust , London , United Kingdom

3. Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery , London , United Kingdom

4. Neuroradiological Academic Unit, Queen Square Institute of Neurology , London , United Kingdom

5. Department of Intensive Care Medicine, University College London Hospitals NHS Foundation Trust , London , United Kingdom

6. Ispat General Hospital , Rourkela , India

7. Center for the Study of Complex Malaria in India, Community Welfare Society Hospital , Rourkela , India

8. University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern , Bern , Switzerland

9. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine , London , United Kingdom

Abstract

Abstract Cerebral malaria is an important cause of mortality and neurodisability in endemic regions. We show magnetic resonance imaging (MRI) features suggestive of cytotoxic and vasogenic cerebral edema followed by microhemorrhages in 2 adult UK cases, comparing them with an Indian cohort. Long-term follow-up images correlate ongoing changes with residual functional impairment.

Funder

NIH

Medical Research Council

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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