T-SPOT.TB Reactivity in Southern African Children With and Without <i>in Utero</i> Human Immunodeficiency Virus Exposure-Reference-Cited by-同舟云学术

T-SPOT.TB Reactivity in Southern African Children With and Without in Utero Human Immunodeficiency Virus Exposure

Published:2023-06-09 Issue:8 Volume:77 Page:1133-1136
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Iwase Saori C¹²,Edlefsen Paul T³,Bhebhe Lynnette⁴,Motsumi Kesego⁴,Moyo Sikhulile⁴⁵,Happel Anna-Ursula¹²,Shao Danica³,Mmasa Nicholas⁶,Schenkel Sara⁷,Gasper Melanie A⁸,Dubois Melanie⁷⁹,Files Megan A¹⁰,Seshadri Chetan¹⁰,Duffy Fergal⁸,Aitchison John⁸^ORCID,Netea Mihai G¹¹¹²,Jao Jennifer⁴¹³,Cameron Donald W¹⁴,Gray Clive M¹²¹⁵,Jaspan Heather B¹²⁸,Powis Kathleen M⁴⁵¹⁶

Affiliation:

1. Division of Immunology, Department of Pathology, University of Cape Town , Cape Town , South Africa

2. Institute of Infectious Disease and Molecular Medicine, University of Cape Town , Cape Town , South Africa

3. Vaccine and Infectious Disease Division, Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

4. Botswana Harvard AIDS Institute Partnership , Gaborone , Botswana

5. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health , Boston, Massachusetts , USA

6. Surgical Department, County Durham and Darlington NHS Trust, Darlington Memorial Hospital , Darlington , United Kingdom

7. Division of Pediatric Global Health, Massachusetts General Hospital , Boston, Massachusetts , USA

8. Center for Global Infectious Disease Research, Seattle Children’s Research Institute, Seattle, Washington, USA

9. Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital , Boston, Massachusetts , USA

10. Department of Medicine, University of Washington School of Medicine , Seattle, Washington , USA

11. Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center , Nijmegen , The Netherlands

12. Department of Immunology and Metabolism, Life & Medical Sciences Institute, University of Bonn , Bonn , Germany

13. Department of Pediatrics, Department of Medicine, Northwestern University Feinberg School of Medicine , Chicago, Illinois , USA

14. Divisions of Infectious Diseases and Respirology, University of Ottawa at the Ottawa Hospital , Ottawa , Canada

15. Division of Molecular Biology and Human Genetics, Biomedical Research Institute, Stellenbosch University , Cape Town , South Africa

16. Departments of Internal Medicine and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Abstract Infants who are human immunodeficiency virus (HIV)-exposed uninfected (iHEU) experience higher risk of infectious morbidity than infants HIV-unexposed uninfected (iHUU). We compared tuberculosis (TB) infection prevalence in 418 Bacillus Calmette-Guérin vaccinated sub-Saharan African iHEU and iHUU aged 9–18 months using T-SPOT.TB. Prevalence of TB infection was low and did not differ by HIV exposure status.

Funder

National Institute of Allergies and Infectious Disease

National Institute of Diabetes and Digestive and Kidney Diseases

Global Health Research Initiative

Canadian Institutes of Health Research

Canadian International Development Agency

International Development Research Centre

NIAID

National Institute of Child Health and Human Development

Yoshida Scholarship Foundation

Publisher

Oxford University Press (OUP)