Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs-Reference-Cited by-同舟云学术

Pregnancy and Birth Outcomes in Patients With Multidrug-Resistant Tuberculosis Treated With Regimens That Include New and Repurposed Drugs

Published:2023-08-22 Issue:1 Volume:78 Page:144-148
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Lotia Farrukh Ismat¹^ORCID,Lachenal Nathalie²,Adenov Malik M³,Ahmed Saman¹,Algozhin Yerkebulan⁴,Coutisson Sylvine²,Garavito Epifanio Sánchez⁵,Hewison Catherine⁶^ORCID,Holtzman David⁷,Huerga Helena⁸^ORCID,Janmohamed Aleeza¹,Khan Palwasha Y¹⁹,Jacques Gamarly Leblanc¹⁰,Lomtadze Nino¹¹,Melikyan Nara¹²,Mitnick Carole D¹³¹⁴,Mussabekova Gulnaz³,Osso Elna¹³,Perea Sara¹⁵,Putri Fauziah Asnely¹⁶,Rashidov Mahmud⁴,Rich Michael L¹⁴¹⁷,Sakhabutdinova Yekaterina⁴,Seung Kwonjune J¹⁴¹⁷,Stambekova Assel⁴,Vásquez Dante Vargas¹⁸,Franke Molly F¹³,Khan Uzma¹

Affiliation:

1. Interactive Research and Development Pakistan , Karachi , Pakistan

2. Pharmacovigilance Unit, Médecins Sans Frontières , Geneva , Switzerland

3. National Scientific Center of Phthisiopulmonology, Ministry of Health, Republic of Kazakhstan , Almaty , Kazakhstan

4. Partners In Health , Almaty , Kazakhstan

5. Centro de Investigación de Enfermedades Neumológicas, Hospital Nacional Sergio Bernale , Lima , Peru

6. Medical Department, Médecins Sans Frontières , Paris , France

7. Partners In Health , Maseru , Lesotho

8. Field Epidemiology Department, Epicentre , Paris , France

9. London School of Hygiene & Tropical Medicine , London , United Kingdom

10. Zanmi Lasante , Cange , Haiti

11. Surveillance and Strategic Planning, Ministry of Health , Tbilisi , Georgia

12. Field Epidemiology Department, Epicentre , Yerevan , Armenia

13. Department of Global Health and Social Medicine, Harvard Medical School , Boston, Massachusetts , USA

14. Partners In Health , Boston, Massachusetts , USA

15. Socios En Salud Sucursal Peru , Lima , Peru

16. Interactive Research and Development Global , Jakarta , Indonesia

17. Division of Global Health Equity, Brigham and Women's Hospital , Boston, Massachusetts , USA

18. Centro de Investigación, Hospital Nacional Hipólito Unanue , Lima , Peru

Abstract

Abstract Among 43 pregnant women receiving multidrug-resistant/rifampicin-resistant tuberculosis (MDR/RR-TB) treatment with bedaquiline and/or delamanid, 98% had favorable treatment outcomes. Of 31 continued pregnancies, 81% had live births with no reported malformations, and 68% of neonates had normal birth weights. Effective MDR/RR-TB treatment during pregnancy can improve maternal outcomes without harming neonates.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciad445/51218204/ciad445.pdf

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