Severe Mpox Infections in People With Uncontrolled Human Immunodeficiency Virus

Author:

Govind Anusha12,Lazarte Susana M12,Kitchell Ellen12,Chow Jeremy Y12,Estelle Carolee D12,Fixsen Emma3,Helm Caitlin4,Jain Mamta K12,Mehta Roma5,Perl Trish M12,Sutaria Jaini M26,Thomas Cristina34,Dominguez Arturo R34,Utay Netanya S12

Affiliation:

1. Division of Infectious Diseases and Geographic Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center , Dallas, Texas , USA

2. Parkland Health , Dallas, Texas , USA

3. Department of Dermatology, University of Texas Southwestern Medical Center , Dallas, Texas , USA

4. Department of Internal Medicine, University of Texas Southwestern Medical Center , Dallas, Texas , USA

5. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center , Dallas, Texas , USA

6. Division of Hospital Medicine, Department of Internal Medicine, University of Texas Southwestern Medical Center , Dallas, Texas , USA

Abstract

Abstract In the current mpox outbreak, infections are usually self-limited. We describe 3 patients with uncontrolled HIV and mpox infections lasting months, causing debilitating lesions, complications, and death, despite initiating anti-mpox and antiretroviral therapy. Delayed treatment of mpox with antiviral agents may contribute to poor outcomes in severely immunocompromised patients.

Funder

University of Texas Southwestern Medical Center

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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