Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant Recipients-Reference-Cited by-同舟云学术

Association of Cytomegalovirus (CMV) DNAemia With Long-Term Mortality in a Randomized Trial of Preemptive Therapy and Antiviral Prophylaxis for Prevention of CMV Disease in High-Risk Donor Seropositive, Recipient Seronegative Liver Transplant Recipients

Published:2023-10-20 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Kumar Lakshin¹^ORCID,Dasgupta Sayan²^ORCID,Murray-Krezan Cristina³,Singh Nina⁴,Rakita Robert M¹,Fisher Cynthia E¹,Limaye Ajit P¹^ORCID

Affiliation:

1. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington , Seattle, Washington , USA

2. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center , Seattle, Washington , USA

3. Division of General Internal Medicine, Department of Medicine, University of Pittsburgh School of Medicine , Pittsburgh, Pennsylvania , USA

4. Department of Medicine, VA Pittsburgh Healthcare System and University of Pittsburgh , Pittsburgh, Pennsylvania , USA

Abstract

Abstract In a post-hoc analysis of the association of CMV DNAemia with long-term mortality in a randomized trial of CMV preemptive therapy vs. antiviral prophylaxis in D+R- liver transplant recipients, post-intervention CMV DNAemia was associated with increased mortality after adjusting for study arm.

Funder

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciad643/52799526/ciad643.pdf

Reference11 articles.

1. Effect of preemptive therapy vs antiviral prophylaxis on cytomegalovirus disease in seronegative liver transplant recipients with seropositive donors: a randomized clinical trial;Singh;JAMA,2020

2. Time-varying covariates and coefficients in Cox regression models;Zhang;Ann Transl Med,2018