The ubiquitin codes in cellular stress responses

Author:

Sheng Xiangpeng123,Xia Zhixiong12,Yang Hanting4ORCID,Hu Ronggui12ORCID

Affiliation:

1. Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou 310024 , China

2. State Key Laboratory of Molecular Biology, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai 200031 , China

3. State Key Laboratory of Animal Disease Control, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Harbin 150069 , China

4. Department of Neurology, State Key Laboratory of Medical Neurobiology, Institute for Translational Brain Research, MOE Frontiers Center for Brain Science, Zhongshan Hospital, Fudan University , Shanghai 200032 , China

Abstract

Abstract Ubiquitination/ubiquitylation, one of the most fundamental post-translational modifications, regulates almost every critical cellular process in eukaryotes. Emerging evidence has shown that essential components of numerous biological processes undergo ubiquitination in mammalian cells upon exposure to diverse stresses, from exogenous factors to cellular reactions, causing a dazzling variety of functional consequences. Various forms of ubiquitin signals generated by ubiquitylation events in specific milieus, known as ubiquitin codes, constitute an intrinsic part of myriad cellular stress responses. These ubiquitination events, leading to proteolytic turnover of the substrates or just switch in functionality, initiate, regulate, or supervise multiple cellular stress-associated responses, supporting adaptation, homeostasis recovery, and survival of the stressed cells. In this review, we attempted to summarize the crucial roles of ubiquitination in response to different environmental and intracellular stresses, while discussing how stresses modulate the ubiquitin system. This review also updates the most recent advances in understanding ubiquitination machinery as well as different stress responses and discusses some important questions that may warrant future investigation.

Funder

Ministry of Science and Technology of China

National Science and Technology Innovation 2030 Major Project of China

Department of Science and Technology of Zhejiang Province

Guangzhou Science Innovation and Development Program

Shenzhen-Hong Kong Institute of Brain Science

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Drug Discovery,Biochemistry,Biotechnology

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