DCK confers sensitivity of DCTD-positive cancer cells to oxidized methylcytidines

Author:

Zhao Ya-Hui1ORCID,Jiang Wei2,Gao Hai13,Pang Guo-Zheng1,Wu Yu-Shuang1,Wang Yuan-Xian1,Sheng Meng-Yao1,Xie Jia-Ying1,Wu Wan-Ling4,Ji Zhi-Jian2,Du Ya-Rui2,Zhang Lei5,Wang Xiao-Qin4,Walsh Colum P67,Jiang Hai2ORCID,Xu Guo-Liang12ORCID,Zhou Dan13ORCID

Affiliation:

1. Shanghai Key Laboratory of Medical Epigenetics, Laboratory of Cancer Epigenetics, Institutes of Biomedical Sciences, Medical College of Fudan University, Chinese Academy of Medical Sciences (RU069) , Shanghai 200032 , China

2. State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai 200031 , China

3. Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University , Shanghai 201399 , China

4. Department of Hematology, Huashan Hospital of Fudan University , Shanghai 200040 , China

5. Department of Chemistry and Institutes of Biomedical Science, Shanghai Medical College, Fudan University , Shanghai 200032 , China

6. Genomic Medicine Research Group, Biomedical Sciences, Ulster University , Coleraine BT52 1SA , United Kingdom

7. Centre for Research and Development, Region Gävleborg/Uppsala University , Gävle SE-801 87 , Sweden

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Drug Discovery,Biochemistry,Biotechnology

Reference15 articles.

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2. A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress;Bruno;Nat Med,2017

3. High cytidine deaminase expression in the liver provides sanctuary for cancer cells from decitabine treatment effects;Ebrahem;Oncotarget,2012

4. Targeting the nucleotide salvage factor DNPH1 sensitizes BRCA-deficient cells to PARP inhibitors;Fugger;Science,2021

5. Degradation of 1-beta-D- ­arabinofuranosylcytosine 5’-triphosphate in human leukemic myeloblasts and lymphoblasts;Jamieson;Cancer Res,1987

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