Single-dose AAV-based vaccine induces a high level of neutralizing antibodies against SARS-CoV-2 in rhesus macaques

Author:

Tong Dali1,Zhang Mei12,Yang Yunru12,Xia Han34,Tong Haiyang5,Zhang Huajun4,Zeng Weihong2,Liu Muziying6,Wu Yan4,Ma Huan2,Hu Xue3,Liu Weiyong1,Cai Yuan1,Yao Yanfeng4,Yao Yichuan12,Liu Kunpeng3,Shan Shifang7,Li Yajuan8,Gao Ge4,Guo Weiwei3,Peng Yun4,Chen Shaohong3,Rao Juhong3,Zhao Jiaxuan3,Min Juan4,Zhu Qingjun5,Zheng Yanmin5,Liu Lianxin1,Shan Chao3,Zhong Kai5,Qiu Zilong7,Jin Tengchuan12ORCID,Chiu Sandra12,Yuan Zhiming4,Xue Tian1279

Affiliation:

1. First Affiliated Hospital of USTC, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230026 , China

2. Hefei National Research Center for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, CAS Key Laboratory of Innate Immunity and Chronic Disease, Biomedical Sciences and Health Laboratory of Anhui Province, University of Science and Technology of China , Hefei 230026 , China

3. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 , China

4. Center for Biosafety Mega-Science, Wuhan Institute of Virology, Chinese Academy of Sciences , Wuhan 430071 , China

5. Hefei Institutes of Physical Science, Chinese Academy of Sciences , Hefei 230031 , China

6. Anhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital , Hefei 230051 , China

7. Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences , Shanghai 200031 , China

8. Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University , Hefei, 230022 , China

9. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences , Beijing 100101 , China

Publisher

Springer Science and Business Media LLC

Subject

Cell Biology,Drug Discovery,Biochemistry,Biotechnology

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