Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis-Reference-Cited by-同舟云学术

Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis

Published:2024-03-02 Issue:9 Volume:15 Page:686-703
ISSN:1674-800X
Container-title:Protein & Cell
language:en
Short-container-title:

Author:

Liu Xiaoguang¹^ORCID,Chen Zhen¹^ORCID,Yan Yuelong¹^ORCID,Zandkarimi Fereshteh²^ORCID,Nie Litong¹^ORCID,Li Qidong¹^ORCID,Horbath Amber¹^ORCID,Olszewski Kellen³⁴^ORCID,Kondiparthi Lavanya³^ORCID,Mao Chao¹^ORCID,Lee Hyemin¹^ORCID,Zhuang Li¹,Poyurovsky Masha³^ORCID,Stockwell Brent R²^ORCID,Chen Junjie¹⁵^ORCID,Gan Boyi¹⁵^ORCID

Affiliation:

1. Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center , Houston, TX 77030 , USA

2. Department of Biological Sciences and Department of Chemistry, Columbia University , New York, NY 10027 , USA

3. Kadmon Corporation, LLC (A Sanofi Company) , New York, NY 10016 , USA

4. The Barer Institute , Philadelphia, PA 19104 , USA

5. The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences , Houston, TX 77030 , USA

Abstract

Abstract Ferroptosis has been recognized as a unique cell death modality driven by excessive lipid peroxidation and unbalanced cellular metabolism. In this study, we established a protein interaction landscape for ferroptosis pathways through proteomic analyses, and identified choline/ethanolamine phosphotransferase 1 (CEPT1) as a lysophosphatidylcholine acyltransferase 3 (LPCAT3)-interacting protein that regulates LPCAT3 protein stability. In contrast to its known role in promoting phospholipid synthesis, we showed that CEPT1 suppresses ferroptosis potentially by interacting with phospholipases and breaking down certain pro-ferroptotic polyunsaturated fatty acid (PUFA)-containing phospholipids. Together, our study reveals a previously unrecognized role of CEPT1 in suppressing ferroptosis.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/proteincell/advance-article-pdf/doi/10.1093/procel/pwae004/57126213/pwae004.pdf

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