Probing the Catalytic Center of Porcine Aminoacylase 1 by Site-Directed Mutagenesis, Homology Modeling and Substrate Docking

Author:

Liu Zhigang,Zhen Zhongliang,Zuo Zhenyu,Wu Yingliang,Liu Aifu,Yi Qingming,Li Wenxin

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,General Medicine

Reference39 articles.

1. Wang, HR., Zhang, T., Wang, ZF., Wang, XC., and Zhou, HM. (1995) Aminoacylase from pig kidney contains no disulfide bonds. Sci. China Ser. B38, 1448–1454

2. Palm, G.J. and Röhm, K.H. (1995) Aminoacylase 1 from porcine kidney: Identification and characterization of two major protein domains. J. Protein Chem.14, 233–240

3. Tsunasawa, S., Narita, K., and Ogata, K. (1975) Purification and properties of acylamino acid-releasing enzyme from rat liver. J. Biochem.77, 89–102

4. Mitta, M., Kato, I., and Tsunasawa, S. (1993) The mucleotide sequence of human aminoacylase-1. Biochimica et Biophysica Acta1174, 201–203

5. Tsunasawa, S. (1992) Does uncontrolled survival of acetylated peptides lead to cell proliferation? Deletion of N-terminal deacetylating system for protein/peptide in small lung carcinoma cells. J. Lab. Clin. Med.120, 505–506

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