Glucocerebrosidase 1 deficientDanio reriomirror key pathological aspects of human Gaucher disease and provide evidence of early microglial activation preceding alpha-synuclein-independent neuronal cell death

Author:

Keatinge Marcus,Bui Hai,Menke Aswin,Chen Yu-Chia,Sokol Anna M.,Bai Qing,Ellett Felix,Da Costa Marc,Burke Derek,Gegg Matthew,Trollope Lisa,Payne Thomas,McTighe Aimee,Mortiboys Heather,de Jager Sarah,Nuthall Hugh,Kuo Ming-Shang,Fleming Angeleen,Schapira Anthony H.V.,Renshaw Stephen A.,Highley J. Robin,Chacinska Agnieszka,Panula Pertti,Burton Edward A.,O'Neill Michael J.,Bandmann Oliver

Funder

BBSRC/Lilly

Parkinson's UK

The Academy of Finland and Sigrid Juselius Foundation

FishMed/EU Seventh Framework Programme

Wellcome Trust/MRC Joint call in Neurodegeneration award to the UK Parkinson’s Disease Consortium

National Institute for Environmental Health Sciences

Australian NHMRC C.J. Martin fellowship

University of Sheffield Vice-Chancellor's Fellowship (PME)

Wellcome Trust

MBB/BMS Light Microscopy Facility

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference54 articles.

1. Gaucher disease: the metabolic defect, pathophysiology, phenotypes and natural history;Baris;Pediatr. Endocrinol. Rev.,2014

2. Management of Gaucher disease: enzyme replacement therapy;Zimran;Pediatr. Endocrinol. Rev.,2014

3. Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

4. Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

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