Paracingulate Sulcus Length and Cortical Thickness in Schizophrenia Patients With and Without a Lifetime History of Auditory Hallucinations

Author:

Ćurčić-Blake Branislava1ORCID,de Vries Annemarie1,Renken Remco J1,Marsman Jan Bernard C1,Garrison Jane2,Hugdahl Kenneth345,Aleman André16

Affiliation:

1. Department of Biomedical Sciences of Cells and Systems, University of Groningen, University Medical Center Groningen , Groningen , The Netherlands

2. Department of Psychology, University of Cambridge , Cambridge , UK

3. Department of Psychiatry, Haukeland University Hospital , Bergen , Norway

4. Department of Radiology, Haukeland University Hospital , Bergen , Norway

5. Department of Biological and Medical Psychology, University of Bergen , Norway

6. Magnetic Resonance Imaging Center, Shenzhen Key Laboratory of Affective and Social Neuroscience, Center for Brain Disorders and Cognitive Sciences, Shenzhen University , Shenzhen , China

Abstract

AbstractBackgroundIt has been theorized that hallucinations, a common symptom of schizophrenia, are caused by failures in reality monitoring. The paracingulate sulcus (PCS) has been implicated as a brain structure supporting reality monitoring with the absence or shorter length of PCS associated with an occurrence of hallucinations in schizophrenia. The absence or shorter length of PCS has been associated with an occurrence of hallucinations. There are inconsistent findings in the literature regarding the role of the asymmetry of this structure for hallucinations. Here, we investigated the length of the PCS and cortical thickness of surrounding structures in patients with a lifetime history of auditory verbal hallucinations (AVH).DesignSeventy-seven patients and twenty-eight healthy controls (HC) underwent an anatomical MRI scan. PCS length and cortical thickness were estimated using Mango brain visualization and FreeSurfer, respectively. Patients with AVH (n = 45) and patients without AVH were compared (n = 32) to the controls.ResultsPCS length significantly differed between HC and patient groups (F(2,102) = 3.57, P = .032) in the left but not in the right sulcus. We found significantly longer PCS between HC and AVH group but no difference between patient groups. Similarly, we found significant thinning of cortical structures including structures surrounding anterior parts of PCS between HC and patients either in general or per group, but no significant differences were observed between patient groups.ConclusionsPCS length in the left hemisphere is shorter in schizophrenia patients with hallucinations as compared to HC subjects. The patient group without hallucinations was in between those 2 groups. Cortical thickness of neighboring areas of PCS is diminished in patient groups relative to the healthy comparison subjects. The role of lateralization and functional involvement of the PCS region in processes underlying hallucinations, such as reality monitoring, needs further clarification.

Funder

University Medical Center Groningen

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

Reference46 articles.

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