Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies—PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice-Reference-Cited by-同舟云学术

Towards Precision Medicine in Psychosis: Benefits and Challenges of Multimodal Multicenter Studies—PSYSCAN: Translating Neuroimaging Findings From Research into Clinical Practice

Published:2019-08-19 Issue:2 Volume:46 Page:432-441
ISSN:0586-7614
Container-title:Schizophrenia Bulletin
language:en
Short-container-title:

Author:

Tognin Stefania¹²,van Hell Hendrika H³,Merritt Kate¹,Winter-van Rossum Inge³,Bossong Matthijs G³,Kempton Matthew J¹,Modinos Gemma¹,Fusar-Poli Paolo¹⁴⁵,Mechelli Andrea¹^ORCID,Dazzan Paola¹,Maat Arija³,de Haan Lieuwe⁶,Crespo-Facorro Benedicto⁷⁸⁹,Glenthøj Birte¹⁰¹¹,Lawrie Stephen M¹²,McDonald Colm¹³,Gruber Oliver¹⁴,van Amelsvoort Therese¹⁵,Arango Celso¹⁶,Kircher Tilo¹⁷,Nelson Barnaby¹⁸¹⁹,Galderisi Silvana²⁰,Bressan Rodrigo²¹,Kwon Jun S²²,Weiser Mark²³²⁴,Mizrahi Romina²⁵²⁶²⁷,Sachs Gabriele²⁸,Maatz Anke²⁹,Kahn René³³⁰,McGuire Phillip¹²⁵, ,McGuire Philip³¹⁵,Tognin Stefania³¹,Fusar-Poli Paolo³¹⁵,Kempton Matthew³¹,Modinos Gemma³¹,Merritt Kate³¹,Mechelli Andrea³¹,Dazzan Paola³¹,Gifford George³¹,Petros Natalia³¹,Antoniades Mathilde³¹,De Micheli Andrea³¹,Vieira Sandra³¹,Spencer Tom J³¹,Scarpazza Cristina³¹,Hird Emily³¹,Kahn Rene³²³³,Maat Arija³²,van Hell Erika³²,Winter Inge³²,Cahn Wiepke³²,Schnack Hugo³²,de Haan Lieuwe³⁴,Siegmann Dieuwke³⁴,Barkhof Jana³⁴,Hendriks Lotte³⁴,de Wit Iris³⁴,Crespo-Facorro Benedicto³⁵³⁶,Tordesillas-Gutierrez Diana³⁵³⁶,Setien-Suero Esther³⁵³⁶,Ayesa-Arriola Rosa³⁵³⁶,Suarez-Pinilla Paula³⁵³⁶,Ramirez-Bonilla MariaLuz³⁵³⁶,Garcia-de la foz Victor Ortiz³⁵³⁶,Glenthøj Birte³⁷³⁸,Erlang Sørensen Mikkel³⁷,Tangmose Karen³⁷³⁸,Schæbel Helle³⁷,Broberg Brian³⁷,Rostrup Egill³⁷³⁹,Lawrie Stephen¹²,McDonald Colm¹³,Hallahan Brian¹³,Cannon Dara¹³,McLoughlin James¹³,Finnegan Martha¹³,Gruber Oliver¹⁴,van Amelsvoort Therese¹⁵⁴⁰,Deckers Danny¹⁵⁴⁰,Marcelis Machteld¹⁵⁴⁰,Vingerhoets Claudia¹⁵,Arango Celso⁴¹,Díaz-Caneja Covadonga M⁴¹,Ayora Miriam⁴¹,Janssen Joost⁴¹,Rodríguez-Jiménez Roberto⁴²,Díaz-Marsá Marina⁴³,Kircher Tilo⁴⁴,Falkenberg Irina⁴⁴,Bitsch Florian⁴⁴,Berger Philipp⁴⁴,Sommer Jens⁴⁴⁴⁵,Raab Kyeon⁴⁴,Jakobi Babette⁴⁴,Nelson Barnaby⁴⁶¹⁹,McGorry Patrick⁴⁶¹⁹,Amminger Paul⁴⁶¹⁹,McHugh Meredith⁴⁶¹⁹,Galderisi Silvana⁴⁷,Mucci Armida⁴⁷,Bucci Paola⁴⁷,Piegari Giuseppe⁴⁷,Pietrafesa Daria⁴⁷,Nicita Alessia⁴⁷,Patriarca Sara⁴⁷,Bressan Rodrigo⁴⁸,Zugman André⁴⁸,Gadelha Ary⁴⁸,Rodrigues da Cunha Graccielle⁴⁸,Soo Kwon Jun⁴⁹,Kevin Cho Kang I k⁴⁹,Young Lee Tae⁴⁹,Kim Minah⁴⁹,Bin Kwak Yoo⁴⁹,Jeong Hwang Wu⁴⁹,Weiser Mark⁵⁰,Mizrahi Romina⁵¹⁵²⁵³,Kiang Michael⁵¹⁵²⁵³,Gerritsen Cory⁵²⁵³,Maheandiran Margaret⁵²,Ahmed Sarah⁵¹⁵²,Prce Ivana⁵²,Lepock Jenny⁵¹⁵²,Sachs Gabriele⁵⁴,Willeit Matthäus⁵⁴,Lenczowski Marzena⁵⁴,Sauerzopf Ullrich⁵⁴,Weidenauer Ana⁵⁴,Furtner-Srajer Julia⁵⁵,Kirschner Matthias⁵⁶⁵⁷,Maatz Anke⁵⁶,Burrer Achim⁵⁶,Stämpfli Philipp⁵⁶,Huber Naemi⁵⁶,Kaiser Stefan⁵⁸⁵⁹,Kawohl Wolfram⁶⁰,Brammer Michael⁶¹,Young Jonathan⁶²³¹,Bullmore Edward⁶³,Morgan Sarah⁶³

Affiliation:

1. Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK

2. Outreach and Support in South London (OASIS), South London and Maudsley NHS Foundation Trust, London, UK

3. Department of Psychiatry, University Medical Center Utrecht Brain Center, Utrecht, the Netherlands

4. Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy

5. National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London, UK

6. Department Early Psychosis, Psychiatry, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands

7. CIBERSAM, Department of Psychiatry, University Hospital Virgen del Rocío, Sevilla, Spain

8. IDIVAL, Marqués de Valdecilla University Hospital, Santander, Spain

9. School of Medicine, University of Cantabria, Santander, Spain

10. Centre for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark

11. Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark

12. Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK

13. Centre for Neuroimaging & Cognitive Genomics (NICOG), NCBES Galway Neuroscience Centre, National University of Ireland Galway, Galway, Ireland

14. Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany

15. Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands

16. Department of Child and Adolescent Psychiatry, Institute of Psychiatry and Mental Health, Hospital General Universitario Gregorio Marañon, CIBERSAM, School of Medicine, Universidad Complutense, Madrid, Spain

17. Department of Psychiatry, University of Marburg, Marburg, Germany

18. Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Australia

19. Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia

20. Department of Psychiatry, University of Campania Luigi Vanvitelli, Naples, Italy

21. Interdisciplinary Lab for Clinical Neurosciences (LiNC), Department of Psychiatry, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil

22. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea

23. Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel

24. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

25. Institute of Medical Science, University of Toronto, Toronto, Canada

26. Centre for Addiction and Mental Health, Toronto, Canada

27. Department of Psychiatry, University of Toronto, Toronto, Canada

28. Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria

29. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Zurich, Switzerland

30. Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY

31. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London, UK

32. University Medical Center, Division of Neurosciences, Department of Psychiatry, Heidelberglaan, CX Utrecht, The Netherlands

33. Department of Psychiatry and Behavioral Health System, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY

34. Amsterdam UMC, University of Amsterdam, Psychiatry, Department Early Psychosis, Meibergdreef, Amsterdam, The Netherlands

35. CIBERSAM, Department of Psychiatry, University Hospital Virgen del Rocío, Sevilla; Marqués de Valdecilla University Hospital, IDIVAL. School of Medicine, University of Cantabria, Santander, Spain

36. CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Spain

37. Centre for Neuropsychiatric Schizophrenia Research (CNSR) & Centre for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark

38. University of Copenhagen, Faculty of Health and Medical Sciences, Dept. of Clinical Medicine, Copenhagen, Denmark

39. Functional Imaging Unit (FIUNIT), Rigshospitalet Glostrup, University of Copenhagen, Glostrup, Denmark

40. GGZE Mental Health Care, Eindhoven, The Netherlands

41. Servicio de Psiquiatría del Niño y del Adolescente, Hospital General Universitario Gregorio Marañon, Universidad Complutense Madrid, Spain; Centro de Investigación Biomédica en Red de Salud Mental, Madrid, Spain

42. Departmento de Psiquiatría, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain; CIBERSAM (Biomedical Research Networking Centre in Mental Health), Spain

43. Hospital Clínico de San Carlos, Universidad Complutense, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, España

44. Dept of Psychiatry, University of Marburg, Rudolf-Bultmann-Straße 8, Marburg, Germany

45. Core-Facility Brainimaging, Faculty of Medicine, University of Marburg, Parkville, Victoria, Melbourne, Australia

46. Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Victoria, Melbourne, Australia

47. Department of Psychiatry, University of Campania Luigi Vanvitelli, Largo Madonna delle Grazie, Naples, Italy

48. Department of Psychiatry, Interdisciplinary Lab for Clinical Neurosciences (LiNC), Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, Brazil

49. Department of Psychiatry, Seoul National University College of Medicine, Dahakno, Jongno-gu, Seoul, Korea

50. Department of Psychiatry, Sheba Medical Center, Tel Hashomer, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

51. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada

52. Centre for Addiction and Mental Health, Toronto, Ontario, Canada

53. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada

54. Department of Psychology, University of Toronto, Toronto, Ontario, Canada

55. Department of Psychiatry and Psychotherapy, Vienna, Austria

56. Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy Währingergürtel, Vienna

57. Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland

58. Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada

59. Clinical and Experimental Psychopathology Laboratory, Faculty of Medicine, University of Geneva, Switzerland

60. Adult Psychiatry Division, Department of mental health and psychiatry, University Hospitals of Geneva, Switzerland

61. Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, De Crespigny Park, Denmark Hill, London, UK

62. IXICO plc, London, UK

63. Department of Psychiatry, University of Cambridge, Cambridge, UK

Abstract

Abstract In the last 2 decades, several neuroimaging studies investigated brain abnormalities associated with the early stages of psychosis in the hope that these could aid the prediction of onset and clinical outcome. Despite advancements in the field, neuroimaging has yet to deliver. This is in part explained by the use of univariate analytical techniques, small samples and lack of statistical power, lack of external validation of potential biomarkers, and lack of integration of nonimaging measures (eg, genetic, clinical, cognitive data). PSYSCAN is an international, longitudinal, multicenter study on the early stages of psychosis which uses machine learning techniques to analyze imaging, clinical, cognitive, and biological data with the aim of facilitating the prediction of psychosis onset and outcome. In this article, we provide an overview of the PSYSCAN protocol and we discuss benefits and methodological challenges of large multicenter studies that employ neuroimaging measures.

Funder

European Union’s Seventh Framework Programme

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

Link

http://academic.oup.com/schizophreniabulletin/article-pdf/46/2/432/32650105/sbz067.pdf

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