Assessing Trial-by-Trial Electrophysiological and Behavioral Markers of Attentional Control and Sensory Precision in Psychotic and Mood Disorders

Author:

Boudewyn Megan A1ORCID,Erickson Molly A2,Winsler Kurt3,Barch Deanna M4ORCID,Carter Cameron S5,Frank Michael J6,Gold James M7ORCID,MacDonald Angus W8,Ragland J Daniel3,Silverstein Steven M9ORCID,Yonelinas Andrew P 3,Luck Steven J3ORCID

Affiliation:

1. Department of Psychology, University of California, Santa Cruz , California , USA

2. Department of Psychiatry and Behavioral Neuroscience, University of Chicago , Chicago, Illinois , USA

3. Department of Psychology, University of California, Davis , California , USA

4. Department of Psychological and Brain Sciences, Washington University in St. Louis , St. Louis, Missouri , USA

5. Department of Psychiatry and Human Behavior, University of California , Irvine, California , USA

6. Department of Cognitive, Linguistics and Psychological Sciences, Brown University , Providence, Rhode Island , USA

7. Department of Psychiatry, University of Maryland School of Medicine , Baltimore, Maryland , USA

8. Department of Psychology, University of Minnesota , Minneapolis, Minnesota , USA

9. Department of Psychiatry, University of Rochester Medical Center , Rochester, New York , USA

Abstract

Abstract Background and Hypothesis The current study investigated the extent to which changes in attentional control contribute to performance on a visual perceptual discrimination task, on a trial-by-trial basis in a transdiagnostic clinical sample. Study Design Participants with schizophrenia (SZ; N = 58), bipolar disorder (N = 42), major depression disorder (N = 51), and psychiatrically healthy controls (N = 92) completed a visual perception task in which stimuli appeared briefly. The design allowed us to estimate the lapse rate and the precision of perceptual representations of the stimuli. Electroencephalograms (EEG) were recorded to examine pre-stimulus activity in the alpha band (8–13 Hz), overall and in relation to behavior performance on the task. Study Results We found that the attention lapse rate was elevated in the SZ group compared with all other groups. We also observed group differences in pre-stimulus alpha activity, with control participants showing the highest levels of pre-stimulus alpha when averaging across trials. However, trial-by-trial analyses showed within-participant fluctuations in pre-stimulus alpha activity significantly predicted the likelihood of making an error, in all groups. Interestingly, our analysis demonstrated that aperiodic contributions to the EEG signal (which affect power estimates across frequency bands) serve as a significant predictor of behavior as well. Conclusions These results confirm the elevated attention lapse rate that has been observed in SZ, validate pre-stimulus EEG markers of attentional control and their use as a predictor of behavior on a trial-by-trial basis, and suggest that aperiodic contributions to the EEG signal are an important target for further research in this area, in addition to alpha-band activity.

Funder

National Institute of Mental Health

Publisher

Oxford University Press (OUP)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Dysfunctional Alpha Modulation as a Mechanism of Working Memory Impairment in Serious Mental Illness;Biological Psychiatry: Cognitive Neuroscience and Neuroimaging;2024-08

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