Affiliation:
1. Department of Psychiatry, Royal College of Surgeons in Ireland , Dublin 2 , Ireland
2. Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh , Edinburgh, EH10 5HF , UK
3. Department Psychiatry, Beaumont Hospital , Dublin 9 , Ireland
Abstract
Abstract
Background and Hypothesis
Psychotic experiences (PEs) are associated with increased risk for mental disorders, in particular persistent PEs. PEs therefore might be useful within intervention research. We sought to systematically determine the incidence and persistence of PEs in the general population.
Study Design
A double-blind search of databases (Embase, Pubmed PMC, Psychinfo, Medline, and Web of Science) from inception to January 2023 and data extraction, were conducted. Study quality was assessed using the NIH assessment tool. Random effects models were conducted to calculate pooled incidence rate per person-year and proportion of persistent PEs per year. Age and study design were all examined using subgroup analyses. Demographic, risk factors, and outcomes for incidence and persistence of PEs were reported in a narrative synthesis.
Study Results
Using a double-blind screening method for abstract (k = 5763) and full text (k = 250) were screened. In total 91 samples from 71 studies were included, of which 39 were included in a meta-analysis (incidence: k = 17, n = 56 089; persistence: k = 22, n = 81 847). Incidence rate was 0.023 per person-year (95% CI [0.0129;0.0322]). That is, for every 100 people, 2 reported first onset PEs in a year. This was highest in adolescence at 5 per 100(13–17 years). The pooled persistence rate for PEs was 31.0% (95% CI [26.65,35.35]) This was highest in adolescence at 35.8%. Cannabis was particularly associated with incidence of PEs, and persistence of PEs were associated with multiple mental disorders.
Conclusions
Each year incidence of PEs is 2 of every 100 people, and persists each year in 31% of cases, this risk is highest in adolescents.
Funder
European Research Council
Wellcome Trust
Science Foundation Ireland
European Regional Development Fund
FutureNeuro industry partners
Health Research Board
Publisher
Oxford University Press (OUP)
Subject
Psychiatry and Mental health
Cited by
6 articles.
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