Early Childhood Neurocognition in Relation to Middle Childhood Psychotic Experiences in Children at Familial High Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls: The Danish High Risk and Resilience Study-Reference-Cited by-同舟云学术

Early Childhood Neurocognition in Relation to Middle Childhood Psychotic Experiences in Children at Familial High Risk of Schizophrenia or Bipolar Disorder and Population-Based Controls: The Danish High Risk and Resilience Study

Published:2022-12-22 Issue:3 Volume:49 Page:756-767
ISSN:0586-7614
Container-title:Schizophrenia Bulletin
language:en
Short-container-title:

Author:

Knudsen Christina Bruun¹²³,Hemager Nicoline²⁴⁵,Jepsen Jens Richardt Møllegaard²⁴⁵⁶,Gregersen Maja²⁴^ORCID,Greve Aja Neergaard⁷²^ORCID,Andreassen Anna Krogh¹²³,Veddum Lotte¹²³,Brandt Julie Marie²⁴⁸,Krantz Mette Falkenberg²⁴⁵,Søndergaard Anne²⁴⁸,Burton Birgitte Klee⁵⁸⁹,Thorup Anne Amalie Elgaard²⁵⁸,Nordentoft Merete²⁴⁸,Lambek Rikke¹⁰,Mors Ole⁷²,Bliksted Vibeke Fuglsang¹²³

Affiliation:

1. Psychosis Research Unit, Aarhus University Hospital – Psychiatry , Børglumvej 5, 1st floor, 8240 Risskov, Aarhus , Denmark

2. The Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH , Aarhus , Denmark

3. Department of Clinical Medicine, Faculty of Health and Medical Sciences, Aarhus University , Aarhus , Denmark

4. CORE – Copenhagen Research Centre for Mental Health, Mental Health Services in the Capital Region of Denmark, Mental Health Centre Copenhagen , Copenhagen , Denmark

5. Child and Adolescent Mental Health Center, Copenhagen University Hospital – Mental Health Services CPH , Copenhagen , Denmark

6. Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research (CINS) and Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Center, Glostrup, Copenhagen University Hospital – Mental Health Services CPH , Copenhagen , Denmark

7. Psychosis Research Unit, Aarhus University Hospital – Psychiatry , Aarhus , Denmark

8. Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen , Denmark

9. Department of Child and Adolescent Psychiatry, Copenhagen University Hospital – Psychiatry Region Zealand , Roskilde , Denmark

10. Department of Psychology and Behavioral Sciences, Aarhus University , Aarhus , Denmark

Abstract

Abstract Background and Hypothesis Familial high-risk (FHR) studies examining longitudinal associations between neurocognition and psychotic experiences are currently lacking. We hypothesized neurocognitive impairments at age 7 to be associated with increased risk of psychotic experiences from age 7 to 11 in children at familial high risk of schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and population-based controls (PBC), and further, impaired functioning in some neurocognitive functions to be associated with greater risk of psychotic experiences in children at FHR-SZ or FHR-BP relative to PBC. Study Design Neurocognition was assessed at age 7 (early childhood) and psychotic experiences from age 7 to 11 (middle childhood) in 449 children from the Danish High Risk and Resilience Study. The neurocognitive assessment covered intelligence, processing speed, attention, visuospatial and verbal memory, working memory, and set-shifting. Psychotic experiences were assessed through face-to-face interviews with the primary caregiver and the child. Study Results Set-shifting impairments at age 7 were associated with greater risk of psychotic experiences from age 7 to 11 in children at FHR-SZ. Children at FHR-BP and PBC showed no differential associations. Working memory and visuospatial memory impairments were related to increased risk of psychotic experiences across the cohort. However, adjusting for concurrent psychopathology attenuated these findings. Conclusions Early childhood neurocognitive impairments are risk markers of middle childhood psychotic experiences, of which impaired set-shifting appears to further increase the risk of psychotic experiences in children at FHR-SZ. More research is needed to examine longitudinal associations between neurocognitive impairments and psychotic experiences in FHR samples.

Funder

Lundbeck Foundation Initiative for Integrative Psychiatric Research – iPSYCH

TRYG Foundation

Innovation Fund Denmark

Mental Health Services of the Capital Region of Denmark

Aarhus University

Beatrice Surovell Haskell Fund for Child Mental Health Research of Copenhagen

Publisher

Oxford University Press (OUP)

Subject

Psychiatry and Mental health

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